THE CIRCADIAN MELATONIN AND CORTISOL SECRETION PATTERN IN PERMANENT NIGHT-SHIFT WORKERS
THE CIRCADIAN MELATONIN AND CORTISOL SECRETION PATTERN IN PERMANENT NIGHT-SHIFT WORKERS
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DOI：
10.1152/ajpregu.1993.265.1.r261
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发表时间：
1993-07-01
影响因子：
--
通讯作者：
WALDHAUSER, F
中科院分区：
文献类型：
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作者：
RODEN, M;KOLLER, M;WALDHAUSER, F
在长期上夜班的工人中，环境时间信号对昼夜节律系统的影响是相互矛盾的。已经描述了夜间工作时间表的节奏调整，它们对容忍倒班工作的意义正在讨论中。然而，关于这种工作情况对内源性时钟设置的影响的报告是不一致的。我们检查了9名健康的年轻男性固定轮班工人，他们在一周结束的夜间工作时工作满意度很高，而7名男性对照人员的白天工作时间正常。所有受试者在研究机构住院28h，用连续抽血泵每小时采集部分血液，以估计昼夜褪黑激素(MT)和皮质醇的分泌模式。一个对照没有表现出昼夜分泌模式。与其他对照组(n=6)相比，除一名轮班工人外，所有轮班工人的激素谱无明显差异。在轮班工人中，注意到MT幅度有轻微的上升趋势，MT分泌量的两个指标也有增加。1例患者表现出相反的激素节律，MT和皮质醇的相位关系未受干扰，激素幅度不明显。然而，在他的私人生活中，他也表现出了相反的昼夜节奏。收集的数据表明，即使是工作满意度很高的长期夜班员工，通常也不会失去他们内在生物钟的昼夜方向。对于对倒班工作的高耐受性，除了昼夜节律系统的重新定位之外，其他因素可能更重要。
In permanent night shift workers the impact of environmental time cues on the circadian system is conflicting. Rhythm adjustments to the nocturnal work schedule have been described, and their significance for tolerance to shift work is under discussion. Reports concerning the effect of this work situation on the setting of the endogenous clock are, however, inconsistent. We examined nine healthy young male permanent shift workers with high work satisfaction at the end of a week on night work and seven male controls with normal diurnal working hours. All subjects were admitted to a research facility for 28 h, and blood was collected with a continuous-withdrawal pump in portions taken hourly for the estimation of the circadian melatonin (MT) and cortisol secretion pattern. One control did not exhibit a circadian secretion pattern. When compared with the other controls (n = 6), all except one of the shift workers showed no difference in the phase or phase relationship of their hormonal profiles. In the shift workers, a minor trend toward elevation of the MT amplitude and an increase in two indicators for the amount of MT secreted were noticed. One individual displayed inverse hormone rhythms with an undisturbed phase relationship of MT and cortisol and inconspicuous hormone amplitudes. He showed, however, an inverse day-night rhythm in his private life, too. The data collected suggest that even permanent night workers with a high degree of work satisfaction do not usually lose the diurnal orientation of their endogenous clock. Factors other than reorientation of the circadian system may be more important for high tolerance to shift work.