Pain regulation by non-neuronal cells and inflammation.
Pain regulation by non-neuronal cells and inflammation.
复制标题
DOI：
10.1126/science.aaf8924
复制
发表时间：
2016-11-04
期刊：
影响因子：
--
通讯作者：
Zhang YQ
中科院分区：
文献类型：
--
作者：
Ji RR;Chamessian A;Zhang YQ
急性疼痛是保护性的，也是炎症的主要特征。关节炎、神经损伤、癌症和化疗后的慢性疼痛与慢性神经炎症有关，慢性神经炎症是外周或中枢神经系统中的局部炎症。越来越多的证据表明，非神经元细胞，如免疫细胞，神经胶质细胞，角质形成细胞，癌细胞和干细胞，在疼痛的发病机制和解决中发挥积极作用。我们综述了非神经元细胞如何通过分泌调节疼痛的神经活性信号分子与伤害性神经元相互作用。最近的研究还表明，细菌感染通过对感觉神经元的直接作用来调节疼痛，并且伤害感受器中存在特定的受体来检测感染的危险信号。我们还讨论了新的治疗策略，以控制神经炎症的预防和治疗慢性疼痛。
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis, nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a local inflammation in the peripheral or central nervous system. Accumulating evidence suggests that non-neuronal cells such as immune cells, glial cells, keratinocytes, cancer cells, and stem cells, play active roles in the pathogenesis and resolution of pain. We review how non-neuronal cells interact with nociceptive neurons by secreting neuroactive signaling molecules that modulate pain. Recent studies also suggest bacterial infections regulate pain through direct actions on sensory neurons, and specific receptors are present in nociceptors to detect danger signals from infections. We also discuss new therapeutic strategies to control neuroinflammation for the prevention and treatment of chronic pain.