Morphological optimization for access to dual oxidants in biofilms
Morphological optimization for access to dual oxidants in biofilms
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DOI：
10.1073/pnas.1315521110
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发表时间：
2014-01-07
影响因子：
11.1
通讯作者：
Dietrich, Lars E. P.
中科院分区：
文献类型：
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作者：
Kempes, Christopher P.;Okegbe, Chinweike;Dietrich, Lars E. P.
推动生物学研究的一个主要主题是形式和功能之间的关系。特别是，一个长期的目标是了解多细胞进化是如何赋予健康优势的。在这里，我们展示了铜绿假单胞菌的生物膜产生的结构，最大限度地促进细胞繁殖。具体地说，我们建立了群体特征中资源可用性和新陈代谢反应的数学模型。这一分析准确地预测了两种类型的电子受体的测量分布：从大气中获得的氧气和细菌产生的具有氧化还原活性的抗生素吩嗪。利用该模型，我们证明了菌落结构的几何形状在生长效率方面是最优的。因为我们的模型是基于资源动力学的，我们还可以根据电子受体可用性的变化来预测特征几何的变化，包括外部氧气可用性的变化和导致细胞不能生产吩嗪的基因操作。
A major theme driving research in biology is the relationship between form and function. In particular, a longstanding goal has been to understand how the evolution of multicellularity conferred fitness advantages. Here we show that biofilms of the bacterium Pseudomonas aeruginosa produce structures that maximize cellular reproduction. Specifically, we develop a mathematical model of resource availability and metabolic response within colony features. This analysis accurately predicts the measured distribution of two types of electron acceptors: oxygen, which is available from the atmosphere, and phenazines, redox-active antibiotics produced by the bacterium. Using this model, we demonstrate that the geometry of colony structures is optimal with respect to growth efficiency. Because our model is based on resource dynamics, we also can anticipate shifts in feature geometry based on changes to the availability of electron acceptors, including variations in the external availability of oxygen and genetic manipulation that renders the cells incapable of phenazine production.