Imaging approach in radioimmunodetection.
Imaging approach in radioimmunodetection.
复制标题
放射免疫检测中的成像方法。
作者：
F. Deland;E. Kim;G. Simmons;D. Goldenberg
使用针对肿瘤相关抗原的放射性标记抗体对肿瘤进行外部体内成像，需要进行处理以去除干扰的非目标放射性。处理需要使用用与抗体上的放射性核素物理上不同的放射性核素标记的模拟非目标化合物，并从非目标抗体中减去模拟的非目标活性。靶标与非靶标放射性活性增加了 2 倍，从而使肿瘤检出率超过 70%。
External in vivo imaging of tumors with radioactively labeled antibodies to tumor-associated antigens requires processing to remove interfering nontarget radioactivity. Processing entails the use of simulated nontarget compounds labeled with a radionuclide physically different from that on the antibody and substraction of the simulated nontarget activity from the nontargeted antibody. A 2-fold increase of the target to nontarget radioactivity is achieved that has made possible a greater than 70% tumor detection rate.