Atrophy of the hippocampal formation in early familial Alzheimer's disease a longitudinal MRI study of at-risk members of a family with an amyloid precursor protein 717(VAL-GLY) mutation
Atrophy of the hippocampal formation in early familial Alzheimer's disease a longitudinal MRI study of at-risk members of a family with an amyloid precursor protein 717(VAL-GLY) mutation
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DOI：
10.1111/j.1749-6632.1996.tb34423.x
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Rossor, MN
中科院分区：
文献类型：
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作者：
Fox, NC;Warrington, EK;Rossor, MN
从病理学和磁共振成像（MRI）研究中已知海马结构（HF）在已确立的阿尔茨海默病（AD）中变得严重萎缩。本研究通过扫描有发生家族性AD（FAD）风险的受试者，检查是否也可以在非常早期的AD中检测到HP的变化。淀粉样前体蛋白（APP）717缬氨酸甘氨酸突变家系的5名高危成员进行了连续MRI扫描，HP体积测量以及神经和神经心理学评估。在两年的时间内，两名受试者受到临床影响，在症状首次出现的两年内，HP体积损失高达20%。不对称性HP萎缩显示在出现明显症状之前就已存在。这可能对AD的早期诊断具有重要意义。
The hippocampal formation (HF) is known from pathological and magnetic resonance imaging (MRI) studies to become severely atrophied in established Alzheimer's disease (AD). This study examined whether changes in the HP could also be detected in very early AD by scanning subjects at risk of developing familial AD (FAD). Five at risk members of a pedigree with the amyloid precursor protein (APP) 717 valine to glycine mutation underwent serial MRI scanning with volumetric measurement of the HP as well as neurological and neuropsychological assessments. Over a period of two years two subjects became clinically affected, a loss of up to 20% of the volume of the HP occurred in the two years over which symptoms first appeared. Asymmetrical HP atrophy was shown to have been present before the development of overt symptoms. This may have important implications for early diagnosis in AD more generally.