Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefit in patients with gastric cancer
Tumor-infiltrating γδT cells predict prognosis and adjuvant chemotherapeutic benefit in patients with gastric cancer
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肿瘤浸润γδT细胞预测胃癌患者的预后和辅助化疗获益
DOI：
10.1080/2162402x.2017.1353858
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发表时间：
2017-01-01
期刊：
影响因子：
7.2
通讯作者：
Xu, Jiejie
中科院分区：
文献类型：
--
作者：
Wang, Jieti;Lin, Chao;Xu, Jiejie
目的：肿瘤浸润性γ δ T细胞（γ δ TILs）在各种癌症中具有不同的预后价值和功能。本研究的目的是评估γ-δ TILs在胃癌中的作用，患者和方法：一个发现集（n = 190）和一个验证集（n = 273）参与了这项研究。在两组中，TNM II和III期疾病患者用于预测对5-氟尿嘧啶（5-FU）为基础的辅助化疗（ACT）的反应。γ δ TIL定义为强（γ δ T细胞>= 5/HPF）与非强（γ δ T细胞< 5/HPF）。绘制Kaplan-Meier曲线分析生存率。通过多变量考克斯模型评估与γ δ TILs相关的风险比（HR）和95% CI。（HR，0.193; 95% CI，0.097-0.383; P= 5/HPF的患者可以从ACT中获益，与γ δ T细胞< 5/HPF的患者相比，其生存风险降低（HR，0.086; 95%CI，0.023-0.327;发现集P < 0.001;验证集HR，0.077; 95%CI，0.023-0.256; P < 0.001）。目前的研究表明，强烈的γ δ T细胞浸润是胃癌患者的一个独立预后因素，并可预测辅助化疗对生存的益处。TNM II和III疾病患者的化疗。
Purpose: Tumor-infiltrating gamma delta T cells (gamma delta TILs) have different prognostic value and functions among various cancers. The aim of the present study was to evaluate the effect of gamma delta TILs in gastric cancer.Patients and methods: A discovery set (n = 190) and a validation set (n = 273) were involved in this study. Patients with TNM II and III disease were used to predict response to 5-fluorouracil (5-FU)-based adjuvant chemotherapy (ACT) in both sets. gamma delta TILs were defined as intense (gamma delta T cells >= 5/HPF) versus nonintense (gamma delta T cells < 5/HPF). Kaplan-Meier curve was plotted to analysis survival. Hazard ratio (HR) and 95% CI associated with gamma delta TILs were evaluated by multivariable Cox models.Findings: The prognostic value of gamma delta TILs in the discovery set (HR, 0.193; 95% CI, 0.097-0.383; P= 5/HPF could benefit from ACT, with a reduced risk of compromised survival compared with those with gamma delta T cells < 5/HPF (HR, 0.086; 95% CI, 0.023-0.327; P < 0.001 in discovery set; and HR, 0.077; 95% CI, 0.023-0.256; P < 0.001 in validation set).Conclusion: The present study shows that intense gamma delta T cells infiltration is an independent prognostic factor in patients with gastric cancer and is predictive of a survival benefit from adjuvant chemotherapy in patients with TNM II and III disease.