ELEVATED GAMMA-AMINOBUTYRIC-ACID LEVELS ATTENUATE THE METABOLIC RESPONSE TO BILATERAL ISCHEMIA
ELEVATED GAMMA-AMINOBUTYRIC-ACID LEVELS ATTENUATE THE METABOLIC RESPONSE TO BILATERAL ISCHEMIA
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DOI：
10.1111/j.1471-4159.1992.tb09780.x
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发表时间：
1992-02-01
影响因子：
4.7
通讯作者：
MCCANDLESS, DW
中科院分区：
文献类型：
--
作者：
ABEL, MS;MCCANDLESS, DW
双侧缺血已被证明会改变能量代谢物如ATP、磷酸肌酸、葡萄糖和糖原的净脑水平。氨基酸神经递质γ-氨基丁酸（GABA）对神经活动产生紧张性抑制作用。本研究旨在评估GABA水平升高对缺血代谢后遗症的影响。GABA转氨酶抑制剂γ-乙烯基-GABA（GVG;氨己烯酸）的蒙古沙鼠生产之前，双边缺血事件。所有检测区域的GABA水平均升高。能量代谢物的水平也增加了，这表明能量利用减少。在对照动物中，在没有GVG的情况下，1分钟的双侧缺血产生的所有代谢物的水平下降。用GVG预处理的动物，双侧缺血1分钟的影响减弱。这些数据表明，持续活动的水平可能会影响对缺血性损伤的反应。此外，GVG可能具有减少轻微缺血事件影响的临床适应症。
Bilateral ischemia has been shown to alter the net brain levels of energy metabolites such as ATP, phosphocreatine, glucose, and glycogen. The amino acid neurotransmitter gamma-aminobutyric acid (GABA) exerts a tonic inhibitory influence on neural activity. The present studies were designed to evaluate the influence of elevated GABA levels on the metabolic sequelae of ischemia. The GABA transaminase inhibitor gamma-vinyl-GABA (GVG; vigabatrin) was administered to Mongolian gerbils before the production of a bilateral ischemic incident. GABA levels were elevated in all regions assayed. Levels of energy metabolites were also increased, an indication of reduced energy utilization. In control animals, in the absence of GVG, 1 min of bilateral ischemia produced decreases in the levels of all metabolites. In animals pretreated with GVG, the effects of 1 min of bilateral ischemia were attenuated. These data suggest that the level of ongoing activity may affect the response to an ischemic insult. Furthermore, GVG may have a clinical indication in reducing the effect of minor ischemic incidents.