Long-term course of oxaliplatin-induced polyneuropathy: a prospective 2-year follow-up study
Long-term course of oxaliplatin-induced polyneuropathy: a prospective 2-year follow-up study
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DOI：
10.1111/jns.12097
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发表时间：
2014-12-01
影响因子：
3.8
通讯作者：
Kalofonos, Haralabos P.
中科院分区：
文献类型：
--
作者：
Briani, Chiara;Argyriou, Andreas A.;Kalofonos, Haralabos P.
This prospective study sought to identify the potential reversibility of oxaliplatin-induced peripheral neuropathy (OXAIPN) by following-up its long-term course 2 years after discontinuation of oxaliplatin (OXA)-based chemotherapy. Participants were 91 colorectal cancer patients treated with OXA-based chemotherapy. Neurological assessment, clinical Total Neuropathy Score(C) (TNSc(C)) and nerve conduction studies were performed at baseline (T0), the end of chemotherapy (T1) and 2 years (T2) after discontinuation of chemotherapy. A total of 73 of 91 (80%) patients experienced OXAIPN at T1. At a median follow-up of 25 months, persistence of chronic OXAIPN was present in 61 of 73 patients (84%) and complete resolution was present in 12 patients (17%). Longitudinal comparison of TNSc(C) values between T1 and T2 revealed that the overall severity of OXAIPN in those 61 patients significantly decreased over time. Median TNSc(C) values were nine (range: 2-15) at T1 vs. four (range: 2-12) at T2 (P
