Association of nonsuppression of cortisol on the DST with primary polydipsia in chronic schizophrenia.
Association of nonsuppression of cortisol on the DST with primary polydipsia in chronic schizophrenia.
复制标题
DST 皮质醇非抑制与慢性精神分裂症原发性多饮的关联。
DOI：
10.1176/ajp.150.4.653
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Luchins,DJ
中科院分区：
文献类型：
--
作者：
Goldman,MB;Blake,L;Marks,RC;Hedeker,D;Luchins,DJ
METHODThe subjects were 39 male and 14 female research patients, between the ages of I 8 and 60 years, admitted to the University of Chicago Research Unit at Illinois State Psychiatric Institute. All were in good physical health; specifically, none had endocrine disorders, necent substance abuse, or other conditions affecting the DST (2) or fluid intake (9). Each had a consensus discharge diagnosis of schizophrenia according to the Research Diagnostic Criteria (I 0), and each had a DST performed after at least 7 days of treatment with neuroleptic medication.A morning urine sample was obtained and laboratory tests (electrolytes, liver function, BUN, creatinine level, CBC, thyroid function, and toxicology screen) were done on admission. Polydipsia was defined as a urine specific gravity of 1.008 on less at admission. Others have also relied on single samples of urine dilution to define polydip-sia (II), and this appears to provide a reliable index of daily urine volume (1 2). Mean 24-hour urine volumes (measured 3-6 weeks after admission) in a subset of subjects with specific urine gravity of less than 1.008 (N= 6) or greater than 1.008 (N= 4) were 8.5 liters (SD= 4.9) and 2.5 liters (SD= 1.5), respectively(t= 2.76, df= 9, p< O. O4). On admission, all but eight subjects (five polydipsic) completed a 3-week drug-free washout, during which a standard I-mg DST was done. All but three(none polydipsic) were subsequently treated with high-potency neuroleptics, the doses of which were adjusted to maximize clinical response. Three (23%) ofthe 13 polydipsic subjects and I 0 (25%) of the 40 nonpolydipsic subjects were treated with henztropine for parkinsonism. All subjects underwent a second l) ST after admission while they were stabilized on a neuroleptic regimen. A modified Schedule for Affective Disorders and Schizophrenia, Change Version (SADS-C)(13) was completed within I week of the DST for 32 subjects. Each subject provided witnessed, informed written consent for the procedures.
