Two Leishmania species circulating in the Kaleybar focus of infantile visceral leishmaniasis, northwest Iran:: implications for deltamethrin dog collar intervention
Two Leishmania species circulating in the Kaleybar focus of infantile visceral leishmaniasis, northwest Iran:: implications for deltamethrin dog collar intervention
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DOI：
10.1016/j.trstmh.2008.04.026
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发表时间：
2008-09-01
影响因子：
2.2
通讯作者：
Ready, P. D.
中科院分区：
文献类型：
--
作者：
Parvizi, P.;Mazloumi-Gavgani, A. S.;Ready, P. D.
婴儿利什曼原虫是地中海盆地婴儿内脏利什曼病（IVL）的病原体，根据对患者和家犬分离株的同工酶分型，这种寄生虫被认为在伊朗西北部IVL的Kaleybar焦点占主导地位。然而，在目前的调查中，只有五分之一的白蛉感染被发现是L。通过PCR检测和序列分析，对高加索白蛉寄生虫的ITS区rDNA进行了初步研究。其他4例感染均为L. tropica是中东地区人类皮肤利什曼病的病原体，偶尔在伊朗和其他地方的狗和病人的内脏中发现寄生虫。L.在Kaleybar焦点的热带表明，这种寄生虫不是一个短暂的引进。Kaleybar已被用于溴氰菊酯狗项圈干预，以降低L.这显著降低了利什曼原虫感染在儿童和家犬（IVL的通常储存宿主）中的发生率。发现L.热带广泛分布在干预区的心脏进行了讨论。广泛和密集的分类自然利什曼原虫感染是流行病学调查的特点，在新热带地区，目前的报告表明，这也将是必要的，在一些地区的旧世界。(C)2008年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
Leishmania infantum is the causative agent of infantile visceral leishmaniasis (IVL) in the Mediterranean Basin and, based on isoenzyme typing of a few isolates from patients and domestic dogs, this parasite was considered to predominate in the Kaleybar focus of IVL in northwest Iran. However, in the current investigation only one out of five sandfly infections was found to be L. infantum, based on PCR detection and sequencing of parasite internal transcribed spacer (ITS) rDNA infecting Phlebotomus perfiliewi transcaucasicus. The four other infections were of haplotypes of L. tropica, the causative agent of anthroponotic cutaneous leishmaniasis in the Middle East and a parasite occasionally detected in the viscera of dogs and patients in Iran and elsewhere. The widespread distribution of L. tropica in the Kaleybar focus suggests that this parasite is not a transient introduction. Kaleybar has been used for a deltamethrin dog collar intervention to reduce the biting rates of the vectors of L. infantum and this has significantly reduced the incidence of Leishmania infections both in children and the domestic dog, the usual reservoir host of IVL. The implications of finding L. tropica widespread in the heart of the intervention area are discussed. Extensive and intensive typing of natural Leishmania infections is a characteristic of epidemiological investigations in the Neotropics and the current report indicates that this will also be necessary in some regions of the Old World. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.