LOWER POSTERIOR CINGULATE CORTEX GLUTATHIONE LEVELS IN OBSESSIVE-COMPULSIVE DISORDER.
LOWER POSTERIOR CINGULATE CORTEX GLUTATHIONE LEVELS IN OBSESSIVE-COMPULSIVE DISORDER.
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DOI：
10.1016/j.bpsc.2015.12.003
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发表时间：
2016-02-01
期刊：
影响因子：
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通讯作者：
Kaufman MJ
中科院分区：
文献类型：
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作者：
Brennan BP;Jensen JE;Perriello C;Pope HG Jr;Jenike MA;Hudson JI;Rauch SL;Kaufman MJ
一些证据支持这样的假设：大脑中谷胱甘肽（GSH）水平降低，与氧化应激增加有关，可能导致强迫症（OCD）。然而，迄今为止还没有研究调查强迫症患者的脑谷胱甘肽水平。29名强迫症患者和25名年龄、性别和种族匹配的非强迫症患者进行了单体素二维j分辨质子磁共振波谱（MRS）研究，以检测后扣带皮层（PCC）的谷胱甘肽水平。利用LCModel和模拟基集对MRS数据进行分析。以总肌酸（Cr）为参照的组间代谢物差异，以及以耶鲁-布朗强迫症量表（Y-BOCS）测量的代谢物比率与症状严重程度之间的关系，采用线性回归进行分析，并调整年龄、性别和种族。一名强迫症参与者未能产生可用的PCC MRS数据。我们发现，与非强迫症患者相比，强迫症患者的PCC GSH/Cr显著降低（β = - 0.027 [95% CI: - 0.049至- 5.9 × 10 - 3]; P = 0.014）。OCD组PCC GSH/Cr与Y-BOCS总分无显著相关性（β = 5.7 × 10 - 4 [95% CI:−4.8 × 10 - 3至5.9 × 10 - 3]; P = 0.83）。较低的PCC GSH/Cr可能表明强迫症患者该脑区继发于高代谢的氧化应激增加。未来的MRS研究有必要调查其他大脑区域的谷胱甘肽水平，这些区域包括皮质-纹状体-丘脑-皮质回路，被认为在强迫症中是异常的。
Several lines of evidence support the hypothesis that lower cerebral levels of glutathione (GSH), associated with increased oxidative stress, may contribute to obsessive-compulsive disorder (OCD). However, no studies to date have investigated brain GSH levels in individuals with OCD. Twenty-nine individuals with OCD and 25 age-, sex-, and race-matched comparison individuals without OCD underwent single voxel 2D J-resolved proton magnetic resonance spectroscopy (MRS) to examine GSH levels in the posterior cingulate cortex (PCC). MRS data were analyzed using LCModel and a simulated basis set. Group metabolite differences referenced to total creatine (Cr), as well as relationships between metabolite ratios and symptom severity as measured by the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), were analyzed using linear regression with adjustment for age, sex, and race. One OCD participant failed to produce usable PCC MRS data. We found significantly lower PCC GSH/Cr in OCD participants compared with non-OCD participants (β = −0.027 [95% CI: −0.049 to −5.9 × 10−3]; P = 0.014). PCC GSH/Cr was not significantly associated with total Y-BOCS score in the OCD group (β = 5.7 × 10−4 [95% CI: −4.8 × 10−3 to 5.9 × 10−3]; P = 0.83). Lower PCC GSH/Cr may be indicative of increased oxidative stress secondary to hypermetabolism in this brain region in OCD. Future MRS studies are warranted to investigate GSH levels in other brain regions that comprise the cortico-striato-thalamo-cortical circuit thought to be abnormal in OCD.