Transcriptional regulation of gene expression in C. elegans.
Transcriptional regulation of gene expression in C. elegans.
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DOI：
10.1895/wormbook.1.45.2
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发表时间：
2013-06-04
期刊：
影响因子：
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通讯作者：
Okkema P
中科院分区：
文献类型：
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作者：
Reinke V;Krause M;Okkema P
蛋白质编码基因序列通过高度调控的转录过程转化为mRNA。许多基因转录的精确时间和空间控制是后生动物发育的重要组成部分。因此，了解转录控制的分子机制对于理解胚胎发生、胚胎后发育、许多环境相互作用和疾病相关过程中细胞命运的决定至关重要。秀丽隐杆线虫的转录调控研究利用其基因组的简单性和物理特性来定义单细胞和分钟时间尺度分辨率的调控事件。结合该系统的遗传学，秀丽隐杆线虫为研究染色质相关蛋白及其修饰如何与转录因子及其结合位点相互作用，从而通过转录调控精确控制基因表达提供了独特而强大的有利条件。
Protein coding gene sequences are converted to mRNA by the highly regulated process of transcription. The precise temporal and spatial control of transcription for many genes is an essential part of development in metazoans. Thus, understanding the molecular mechanisms underlying transcriptional control is essential to understanding cell fate determination during embryogenesis, post-embryonic development, many environmental interactions, and disease-related processes. Studies of transcriptional regulation in C. elegans exploit its genomic simplicity and physical characteristics to define regulatory events with single cell and minute time scale resolution. When combined with the genetics of the system, C. elegans offers a unique and powerful vantage point from which to study how chromatin-associated protein and their modifications interact with transcription factors and their binding sites to yield precise control of gene expression through transcriptional regulation.