Folic Acid Supplementation for the Prevention of Neural Tube Defects US Preventive Services Task Force Recommendation Statement
Folic Acid Supplementation for the Prevention of Neural Tube Defects US Preventive Services Task Force Recommendation Statement
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DOI：
10.1001/jama.2016.19438
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发表时间：
2017-01-10
影响因子：
120.7
通讯作者：
Tseng, Chien-Wen
中科院分区：
文献类型：
--
作者：
Bibbins-Domingo, Kirsten;Grossman, David C.;Tseng, Chien-Wen
神经管缺陷是美国最常见的主要先天性异常之一，可能导致一系列残疾或死亡。在围受孕期每天补充叶酸可以预防神经管缺陷。然而，大多数妇女没有收到建议的每日摄入量的叶酸从diets.Objective更新2009年美国预防服务工作组（USPSTF）建议补充叶酸的育龄women.Evidence审查在2009年，USPSTF审查的有效性，补充叶酸的育龄妇女对预防婴儿神经管缺陷。目前的审查评估的好处和危害的叶酸supplementary.FINDINGS的USPSTF评估的好处和危害的平衡叶酸补充剂在育龄妇女和确定的净效益是巨大的新证据。有足够的证据表明，以常规剂量补充叶酸对母亲或婴儿的危害不超过很小。因此，USPSTF重申其2009年的建议。结论和建议USPSTF建议所有计划怀孕或有能力怀孕的妇女每天服用含有0.4至0.8毫克（400-800微克）叶酸的补充剂。（A项建议）
IMPORTANCE Neural tube defects are among the most common major congenital anomalies in the United States and may lead to a range of disabilities or death. Daily folic acid supplementation in the periconceptional period can prevent neural tube defects. However, most women do not receive the recommended daily intake of folate from diet alone.OBJECTIVE To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on folic acid supplementation in women of childbearing age.EVIDENCE REVIEW In 2009, the USPSTF reviewed the effectiveness of folic acid supplementation in women of childbearing age for the prevention of neural tube defects in infants. The current review assessed new evidence on the benefits and harms of folic acid supplementation.FINDINGS The USPSTF assessed the balance of the benefits and harms of folic acid supplementation in women of childbearing age and determined that the net benefit is substantial. Evidence is adequate that the harms to the mother or infant from folic acid supplementation taken at the usual doses are no greater than small. Therefore, the USPSTF reaffirms its 2009 recommendation.CONCLUSIONS AND RECOMMENDATION The USPSTF recommends that all women who are planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400-800 mu g) of folic acid. (A recommendation)