MBROLE 2.0-functional enrichment of chemical compounds.
MBROLE 2.0-functional enrichment of chemical compounds.
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DOI：
10.1093/nar/gkw253
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发表时间：
2016-07-08
影响因子：
14.9
通讯作者：
Chagoyen M
中科院分区：
文献类型：
--
作者：
López-Ibáñez J;Pazos F;Chagoyen M
代谢物生物学作用（MBROLE）是一个服务器，执行从代谢组学实验衍生的化合物列表的功能富集分析，这使得该列表可以在生物学术语解释。自2011年发布以来，MBROLE已被世界各地的不同团体用于分析各种生物体的代谢组学实验。这里我们介绍了该系统的最新版本MBROLE2，可从http://csbg.cnb.csic.es/mbrole2访问。MBROLE2增加了10个以前版本中没有的数据库，这些数据库允许对更大、更丰富的词汇集进行分析，包括代谢物-蛋白质和药物-蛋白质相互作用。这个新版本执行来自不同数据库的复合标识符的自动转换，从而简化了使用。此外，用户界面也进行了重新设计，以生成交互式的、更直观的结果表示。
Metabolites Biological Role (MBROLE) is a server that performs functional enrichment analysis of a list of chemical compounds derived from a metabolomics experiment, which allows this list to be interpreted in biological terms. Since its release in 2011, MBROLE has been used by different groups worldwide to analyse metabolomics experiments from a variety of organisms. Here we present the latest version of the system, MBROLE2, accessible at http://csbg.cnb.csic.es/mbrole2. MBROLE2 has been supplemented with 10 databases not available in the previous version, which allow analysis over a larger, richer set of vocabularies including metabolite–protein and drug–protein interactions. This new version performs automatic conversion of compound identifiers from different databases, thus simplifying usage. In addition, the user interface has been redesigned to generate an interactive, more intuitive representation of the results.