Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans
Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans
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DOI：
10.1016/j.envpol.2008.11.004
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发表时间：
2009-04-01
影响因子：
8.9
通讯作者：
Xing, Baoshan
中科院分区：
文献类型：
--
作者：
Wang, Huanhua;Wick, Robert L.;Xing, Baoshan
关于人造氧化纳米颗粒（NPs）的环境行为和相关潜在风险的信息有限。本研究以大肠杆菌为食物来源，研究了纳米颗粒和散装ZnO、Al2O3和TiO2对秀丽隐杆线虫的毒性。同时还对NPs中溶解的金属离子进行了平行实验。评估24小时中位致死浓度（LC50）和亚致死终点。NPs和它们的散装对应物都是有毒的，抑制线虫的生长，特别是繁殖能力。ZnO NPs （2.3 mg L-1）和散装ZnO的24 h LC50差异不显著，但Al2O3 NPs之间差异显著；（82 mg L-1）和散装Al2O3 （153 mg L-1）之间，以及TiO2 NPs （80 mg L-1）和散装TiO2 （136 mg L-1）之间。氧化物溶解度影响ZnO和Al2O3 NPs的毒性，但所研究的NPs确实观察到纳米颗粒依赖性毒性。(C) 2008 Elsevier Ltd版权所有。
Limited information is available on the environmental behavior and associated potential risk of manufactured oxide nanoparticles (NPs). In this research, toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 were examined to the nematode Caenorhabditis elegans with Escherichia coli as a food source. Parallel experiments with dissolved metal ions from NPs were also conducted. The 24-h median lethal concentration (LC50) and sublethal endpoints were assessed. Both NPs and their bulk counterparts were toxic, inhibiting growth and especially the reproductive capability of the nematode. The 24-h LC50 for ZnO NPs (2.3 mg L-1) and bulk ZnO was not significantly different, but significantly different between Al2O3 NPs; (82 mg L-1) and bulk Al2O3 (153 mg L-1), and between TiO2 NPs (80 mg L-1) and bulk TiO2 (136 mg L-1). Oxide solubility influenced the toxicity of ZnO and Al2O3 NPs, but nanoparticle-dependent toxicity was indeed observed for the investigated NPs. (C) 2008 Elsevier Ltd. All rights reserved.