Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs.
Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs.
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DOI：
10.1016/s0952-7915(98)80034-4
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发表时间：
1998-02
影响因子：
7
通讯作者：
I. Wilson;P. Bjorkman
中科院分区：
文献类型：
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作者：
I. Wilson;P. Bjorkman
MHC 折叠具有特征明确的肽结合沟，除了将抗原肽呈递给 T 细胞外，还可以执行其他功能。 MHC 分子的同源物具有多种作用，包括呈递脂质抗原（通过 CD1）、运输免疫球蛋白（通过血色素沉着症基因产物 HFE）和欺骗宿主免疫系统（通过病毒同源物）。最近，两种非标准 MHC 类分子的晶体结构可以将经典 MHC 分子的识别特性与其不寻常的同系物的识别特性进行比较。
The MHC fold, with its well-characterized peptide-binding groove, can perform other functions in addition to presentation of antigenic peptides to T cells. Homologs of MHC molecules have diverse roles that include presentation of lipid antigens (by CD1), transport of immunoglobulins (by the hemochromatosis gene product, HFE), and deception of the host immune system (by viral homologs). Recent crystal structures of two of these non-standard MHC-like molecules have allowed comparison of the recognition properties of classical MHC molecules with those of their unusual homologs.