Another view of the history of antipsychotic drug discovery and development
Another view of the history of antipsychotic drug discovery and development
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DOI：
10.1038/mp.2012.121
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发表时间：
2012-12-01
影响因子：
11
通讯作者：
Davis, J. M.
中科院分区：
文献类型：
--
作者：
Carpenter, W. T., Jr.;Davis, J. M.
60年前，氯丙嗪开创了精神分裂症的有效药物治疗。这一发现引发或刺激了精神病学领域的关键发展。尽管如此，精神分裂症的药物治疗进展不大。精神病仍然是精神病理学的主要方面，核心病理，如认知和阴性症状仍然是未满足的治疗挑战。新的临床和基础神经科学范式可能会指导不久的将来，并为新的和创新的发现提供一个更具启发性的结构。
Chlorpromazine initiated effective pharmacotherapy for schizophrenia 60 years ago. This discovery initiated or stimulated key developments in the field of psychiatry. Nonetheless, advances in pharmacotherapy of schizophrenia have been modest. Psychosis remains the primary aspect of psychopathology addressed, and core pathologies such as cognition and negative symptom remain unmet therapeutic challenges. New clinical and basic neuroscience paradigms may guide the near future and provide a more heuristic construct for novel and innovative discovery.