Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
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DOI：
10.1038/7391
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发表时间：
1999-04-01
期刊：
影响因子：
82.9
通讯作者：
Frank, DW
中科院分区：
文献类型：
--
作者：
Sawa, T;Yahr, TL;Frank, DW
铜绿假单胞菌是一种机会性细菌病原体，可引起危重患者致命的急性肺部感染。肺上皮损伤与毒素的表达有关，毒素通过一种类型介导的分泌和转运机制直接注射到真核细胞中。在这里，我们表明，铜绿假单胞菌的同源耶尔森氏菌V抗原，PcrV，参与了III型毒素的易位。接种PcrV疫苗可确保小鼠存活，减少肺部炎症和损伤。PcrV抗体抑制III型毒素的易位。
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause fatal acute lung infections in critically ill individuals. Damage to the lung epithelium is associated with the expression of toxins that are directly injected into eukaryotic cells through a type Ill-mediated secretion and translocation mechanism. Here we show that the P. aeruginosa homolog of the Yersinia V antigen, PcrV, is involved in the translocation of type III toxins. Vaccination against PcrV ensured the survival of challenged mice and decreased lung inflammation and injury. Antibodies to PcrV inhibited the translocation of type III toxins.