Turning the spotlight on bone marrow adipocytes in haematological malignancy and non‐malignant conditions
Turning the spotlight on bone marrow adipocytes in haematological malignancy and non‐malignant conditions
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DOI：
10.1111/bjh.18748
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发表时间：
2023-04
影响因子：
6.5
通讯作者：
M. Austin;Foteini Kalampalika;W. Cawthorn;B. Patel
中科院分区：
文献类型：
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作者：
M. Austin;Foteini Kalampalika;W. Cawthorn;B. Patel
虽然骨髓脂肪细胞（BMAd）长期以来一直受到临床血液病理学家的重视，但直到最近，面对新出现的数据，脂肪细胞生态位才受到生物学家的关注。现在有越来越多的证据表明，BMAds不仅仅是骨髓微环境的一个简单结构实体，而且是与健康和疾病的多个方面相关的生理和病理生理过程的真正驱动因素。虽然BMAds的真正多面性才刚刚开始出现，但范式已经在正常、恶性和非恶性造血中发生了转变，并纳入了脂肪细胞调节的观点。目前正在进行重大努力，以确定BMAds参与健康和疾病的途径，最终目标是实现临床可追踪性。这篇综述总结了BMAds在正常和病理血液病中的新作用，特别关注它对癌症治疗的影响。
Whilst bone marrow adipocytes (BMAd) have long been appreciated by clinical haemato‐pathologists, it is only relatively recently, in the face of emerging data, that the adipocytic niche has come under the watchful eye of biologists. There is now mounting evidence to suggest that BMAds are not just a simple structural entity of bone marrow microenvironments but a bona fide driver of physio‐ and pathophysiological processes relevant to multiple aspects of health and disease. Whilst the truly multifaceted nature of BMAds has only just begun to emerge, paradigms have shifted already for normal, malignant and non‐malignant haemopoiesis incorporating a view of adipocyte regulation. Major efforts are ongoing, to delineate the routes by which BMAds participate in health and disease with a final aim of achieving clinical tractability. This review summarises the emerging role of BMAds across the spectrum of normal and pathological haematological conditions with a particular focus on its impact on cancer therapy.