Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice.
Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice.
复制标题
急性应激或精神安定药会引起 MPTP 治疗小鼠的感觉运动缺陷。
DOI：
10.1016/0304-3940(88)90443-0
复制
发表时间：
1988
影响因子：
2.5
通讯作者：
Bruno,JP
中科院分区：
文献类型：
--
作者：
Weihmuller,FB;Hadjiconstantinou,M;Bruno,JP
The present study evaluates the effects of MPTP-induced striatal DA depletions on sensorimotor behavior in mice. While MPTP produces no obvious behavioral deficits under normal conditions, acute stress (cold swim) or injection of low doses of haloperidol results in marked akinesia, catalepsy, and sensory neglect. Thus, significant behavioral impairments do accompany the neurotoxicity observed after MPTP administration in mice and render this a valuable animal model for studying mechanisms underlying Parkinson's disease.
