PD-1+ immune cell infiltration inversely correlates with survival of operable breast cancer patients
PD-1+ immune cell infiltration inversely correlates with survival of operable breast cancer patients
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DOI：
10.1007/s00262-014-1519-x
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发表时间：
2014-04-01
影响因子：
5.8
通讯作者：
Shen, Kunwei
中科院分区：
文献类型：
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作者：
Sun, Shenyou;Fei, Xiaochun;Shen, Kunwei
程序性死亡-1（PD-1）分子主要表达在功能“耗竭”的CD 8（+）T细胞上，抑制宿主的抗肿瘤免疫应答。我们评估了有效T细胞和调节性T细胞（TCRs）和PD-1表达之间的比率作为可手术乳腺癌患者的预后因素。对218例在瑞金医院接受过初次手术的新诊断浸润性乳腺癌患者进行了系列识别。利用免疫组织化学分析CD 8（+）细胞毒性T淋巴细胞、FOXP 3（+）（Treg细胞标志物）和PD-1（+）免疫细胞计数对预后的影响。PD-1（+）免疫细胞和FOXP 3（+）T细胞计数均与不良预后因素显著相关。在双变量而非多变量分析中，高肿瘤浸润PD-1（+）细胞计数与患者生存期显著缩短相关。我们的研究结果表明PD-1（+）免疫细胞群体在此类乳腺癌患者中的预后价值。靶向PD-1通路可能是治疗乳腺癌患者的可行方法。
The programmed death-1 (PD-1) molecule is mainly expressed on functionally "exhausted" CD8(+) T cells, dampening the host antitumor immune response. We evaluated the ratio between effective and regulatory T cells (Tregs) and PD-1 expression as a prognostic factor for operable breast cancer patients. A series of 218 newly diagnosed invasive breast cancer patients who had undergone primary surgery at Ruijin Hospital were identified. The influence of CD8(+) cytotoxic T lymphocytes, FOXP3(+) (Treg cell marker), and PD-1(+) immune cell counts on prognosis was analyzed utilizing immunohistochemistry. Both PD-1(+) immune cells and FOXP3(+) Tregs counts were significantly associated with unfavorable prognostic factors. In bivariate, but not multivariate analysis, high tumor infiltrating PD-1(+) cell counts correlated with significantly shorter patient survival. Our results suggest a prognostic value of the PD-1(+) immune cell population in such breast cancer patients. Targeting the PD-1 pathway may be a feasible approach to treating patients with breast cancer.