Differences in estrogen receptor subtype according to family history of breast cancer among Hispanic, but not non-Hispanic White women.
Differences in estrogen receptor subtype according to family history of breast cancer among Hispanic, but not non-Hispanic White women.
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DOI：
10.1158/1055-9965.epi-08-0504
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发表时间：
2008-10
影响因子：
3.8
通讯作者：
Byers, Tim
中科院分区：
文献类型：
--
作者：
Hines, Lisa M.;Risendal, Betsy;Slattery, Martha L.;Baumgartner, Kathy B.;Giuliano, Anna R.;Byers, Tim
在比较不同种族人群时，已经报道了乳腺肿瘤的病理差异。很少有研究评估乳腺癌危险因素与乳腺肿瘤病理特征之间的种族特异性关系。鉴于遗传变异可能导致乳腺癌的种族相关病因学差异，我们假设西班牙裔和非西班牙裔白人（NHW）女性的乳腺癌家族史不同，肿瘤特征也不同。Logistic回归模型用于计算优势比（OR）和95%置信区间（95% CI），以评估基于人群的病例对照4角乳腺癌研究（1,537例和2,452例对照）中的这种关系。在西班牙裔女性中，与没有乳腺癌的女性相比，有家族病史的女性患雌激素受体（ER）阴性的风险增加2.7倍（95% CI, 1.59-4.44），但雌激素受体阳性肿瘤的风险增加2.7倍（OR, 1.04; 95% CI, 0.71-1.54）。相比之下，在NHW女性中，ER阳性的风险增加（OR, 1.89; 95% CI, 1.50-2.38）， ER阴性肿瘤的风险增加（OR, 1.41; 95% CI, 0.92-2.17）。当比较侵袭性病例的肿瘤特征时，有家族史的西班牙裔患者ER阴性肿瘤的比例也显著更高（39.2%比25.8%,P = 0.02），但在非裔美国人中没有（16.3%比21.1%,P = 0.13）。这些结果可能反映了促进特定乳腺癌亚型发展的民族特异性易感遗传因素，并强调了在不同民族人群中评估乳腺癌危险因素与乳腺癌亚型之间关系的重要性。
Pathologic differences have been reported among breast tumors when comparing ethnic populations. Limited research has been done to evaluate the ethnic-specific relationships between breast cancer risk factors and the pathologic features of breast tumors. Given that genetic variation may contribute to ethnic-related etiologic differences in breast cancer, we hypothesized that tumor characteristics differ according to family history of breast cancer among Hispanic and non-Hispanic White (NHW) women. Logistic regression models were used to compute odds ratios (OR) and 95% confidence intervals (95% CI) to assess this relationship in the population-based, case-control 4-Corners Breast Cancer Study (1,537 cases and 2,452 controls). Among Hispanic women, having a family history was associated with a 2.7-fold increased risk of estrogen receptor (ER) negative (95% CI, 1.59-4.44), but not ER positive tumors (OR, 1.04; 95% CI, 0.71-1.54) when compared with women without breast cancer. In contrast, there was an increased risk for ER positive (OR, 1.89; 95% CI, 1.50-2.38) and a marginally significant increased risk for ER negative tumors (OR, 1.41; 95% CI, 0.92-2.17) among NHW women. When comparing tumor characteristics among invasive cases, those with a family history also had a significantly higher proportion of ER negative tumors among Hispanics (39.2% versus 25.8%; P = 0.02), but not among NHWs (16.3% versus 21.1%; P = 0.13). These results may reflect ethnic-specific predisposing genetic factors that promote the development of specific breast tumor subtypes, and emphasize the importance of evaluating the relationship between breast cancer risk factors and breast tumor subtypes among different ethnic populations.