How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?
How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?
复制标题
DOI：
10.1111/j.1600-065x.2011.01060.x
复制
发表时间：
2011-11
影响因子：
8.7
通讯作者：
Hoffmann A
中科院分区：
文献类型：
--
作者：
Schröfelbauer B;Hoffmann A
肿瘤坏死因子受体（TNFR）超家族成员介导细胞对多种生物输入的反应。反应范围从细胞死亡、存活、分化、增殖到免疫调节。所有这些生理反应都是由有限数量的高度多效性激酶调节的。事实上，相同的信号分子参与了TNFR超家族成员的信号转导，这些成员调节不同甚至相反的过程，这就提出了如何确定其特异性的问题。可以有助于信号传导特异性的调控策略包括控制激酶特异性的支架、几种信号转导物的组合使用和信号传导的时间控制。在这篇综述中，我们讨论了TNFR超家族成员信号的背景下，这些策略。
Tumor necrosis factor receptor (TNFR) superfamily members mediate the cellular response to a wide variety of biological inputs. The responses range from cell death, survival, differentiation, proliferation, to the regulation of immunity. All these physiological responses are regulated by a limited number of highly pleiotropic kinases. The fact that the same signaling molecules are involved in transducing signals from TNFR superfamily members that regulate different and even opposing processes raises the question of how their specificity is determined. Regulatory strategies that can contribute to signaling specificity include scaffolding to control kinase specificity, combinatorial use of several signal transducers, and temporal control of signaling. In this review, we discuss these strategies in the context of TNFR superfamily member signaling.