Fibrosis imaging: Current concepts and future directions.
Fibrosis imaging: Current concepts and future directions.
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DOI：
10.1016/j.addr.2017.10.013
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发表时间：
2017-11-01
影响因子：
16.1
通讯作者：
Lammers T
中科院分区：
文献类型：
--
作者：
Baues M;Dasgupta A;Ehling J;Prakash J;Boor P;Tacke F;Kiessling F;Lammers T
纤维化在许多不同的病理中起作用。它由组织损伤、慢性炎症、自身免疫反应和遗传改变引起，其特征在于细胞外基质成分的过度沉积。活检常规用于纤维化诊断，但它们具有几个缺点，包括它们的侵入性、采样可变性和有限的空间信息。为了克服这些限制，多年来已经评估了多种不同的成像工具和技术，包括X射线成像、计算机断层扫描（CT）、超声（US）、磁共振成像（MRI）、正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）。这些模式可以提供解剖，功能和分子成像信息，这是有用的纤维化诊断和分期，他们也可能持有的治疗反应的纵向评估的潜力。在这里，我们总结了非侵入性成像技术用于监测肝，肾，肺和心脏等实质器官，全身性自身免疫性疾病和促纤维增生性癌症中的纤维化，我们讨论了如何将成像生物标志物整合到（前）临床研究中，以个性化和改善抗纤维化治疗。
Fibrosis plays a role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis diagnosis, but they suffer from several drawbacks, including their invasive nature, sampling variability and limited spatial information. To overcome these limitations, multiple different imaging tools and technologies have been evaluated over the years, including x-ray imaging, computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), positron emission tomography (PET) and single-photon emission computed tomography (SPECT). These modalities can provide anatomical, functional and molecular imaging information which is useful for fibrosis diagnosis and staging, and they may also hold potential for the longitudinal assessment of therapy responses. Here, we summarize the use of non-invasive imaging techniques for monitoring fibrosis in parenchymal organs such as liver, kidney, lung and heart, in systemic autoimmune diseases and in desmoplastic cancers, and we discuss how imaging biomarkers can be integrated in (pre-) clinical research to individualize and improve anti-fibrotic therapies.
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影响因子：
14
作者：
Afonso, Luis C.;Bernal, Juan;Abraham, Theodore P.
通讯作者：
Abraham, Theodore P.
影响因子：
29.4
作者：
Angulo P;Kleiner DE;Dam-Larsen S;Adams LA;Bjornsson ES;Charatcharoenwitthaya P;Mills PR;Keach JC;Lafferty HD;Stahler A;Haflidadottir S;Bendtsen F
通讯作者：
Bendtsen F
影响因子：
29.4
作者：
Bachem, MG;Sch端nemann, M;Adler, G
通讯作者：
Adler, G
DOI：
10.1002/art.24646
发表时间：
2009-09-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Backhaus, M.;Ohrndorf, S.;Schmidt, W. A.
通讯作者：
Schmidt, W. A.
影响因子：
5.8
作者：
Beljaars, L;Weert, B;Poelstra, K
通讯作者：
Poelstra, K