Recent Advances in the Chemistry and Pharmacology of Cryptolepine.
Recent Advances in the Chemistry and Pharmacology of Cryptolepine.
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DOI：
10.1007/978-3-030-64853-4_4
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发表时间：
2021-01-01
影响因子：
--
通讯作者：
Wright, Colin W
中科院分区：
文献类型：
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作者：
Shnyder, Steven D;Wright, Colin W
Cryptolepine是西非攀缘灌木Cryptolepis sanguinolenta的主要成分，作为新治疗剂的先导，特别是用于治疗原生动物感染和癌症，仍然令人感兴趣。这篇文章回顾了在过去十年中发表的研究，突出了新的合成路线cryptolepine和这种生物碱的类似物，以及它们的药理学。有关C.讨论了作为治疗疟疾的草药的sanguinolenta，以及作为治疗疟疾、锥虫病和癌症的新药剂的cryptolepine类似物的开发，强调了所涉及的药理学机制。其他潜在的治疗应用包括抗菌，抗糖尿病，抗炎活性，cryptolepine的药代动力学和毒性也进行了审查。
Cryptolepine, the principal constituent of the West African climbing shrub Cryptolepis sanguinolenta, continues to be of interest as a lead to new therapeutic agents, especially for the treatment of protozoal infections and cancer. This contribution reviews the research published in the last decade, highlighting new synthesis routes to cryptolepine and to analogs of this alkaloid, as well as their pharmacology. Studies relating to the use of C. sanguinolenta as an herbal medicine for the treatment of malaria are discussed, as well as the development of analogs of cryptolepine as leads to new agents for the treatment of malaria, trypanosomiasis, and cancer with an emphasis on the pharmacological mechanisms involved. Other potential therapeutic applications include antimicrobial, antidiabetic, and anti-inflammatory activities; the pharmacokinetics and toxicity of cryptolepine are also reviewed.