New advances in ligand design for synthetic modeling of metalloprotein active sites.
New advances in ligand design for synthetic modeling of metalloprotein active sites.
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金属蛋白活性位点合成建模的配体设计新进展。
DOI：
10.1016/s1367-5931(00)00189-7
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发表时间：
2001
影响因子：
7.8
通讯作者：
Spencer,DJ
中科院分区：
文献类型：
--
作者：
Tolman,WB;Spencer,DJ
配体的空间体积和辅助结构元素的明智控制，使新型合成复合物的模型金属蛋白活性位点的性质，从而提供洞察其结构和功能的建设。最近的主要进展包括使用精细的N-供体和O-供体配体合成一些不寻常的和生物相关的铜和铁的络合物。
Judicious control of ligand steric bulk and auxiliary structural elements enables the construction of novel synthetic complexes that model the properties of metalloprotein active sites, thus providing insight into their structure and function. Major recent developments include the synthesis of a number of unusual and biologically relevant complexes of copper and iron using elaborate N-donor and O-donor ligands.