The human TRIDENT/HFH-11/FKHL16 gene:: Structure, localization, and promoter characterization
The human TRIDENT/HFH-11/FKHL16 gene:: Structure, localization, and promoter characterization
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DOI：
10.1006/geno.1997.5065
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发表时间：
1997-12-15
期刊：
影响因子：
4.4
通讯作者：
Clevers, H
中科院分区：
文献类型：
--
作者：
Korver, W;Roose, J;Clevers, H
我们最近在小鼠中鉴定了翼螺旋/叉头转录因子Trident，并描述了其在细胞周期中的表达。在这里，我们报告的分离和鉴定的人TRIDENT（HGMW批准的符号FKHL 16）的cDNA和基因。人类和小鼠Trident蛋白之间的同源性为79%。该基因由10个外显子组成，位于12号染色体p13带。翼状螺旋DNA结合结构域在三个外显子上编码。同步化Rat-1成纤维细胞中启动子的分析揭示了负责TRIDENT基因的细胞周期特异性表达的300个碱基的片段。(C)北京：科学出版社.
We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here we report the isolation and characterization of the human TRIDENT (HGMW-approved symbol FKHL16) cDNA and gene. Homology between the human and the mouse Trident proteins was 79%. The gene consists of 10 exons and is located on chromosome 12 band p13. The winged-helix DNA-binding domain is encoded on three exons. Analysis of the promoter in synchronized Rat-1 fibroblasts revealed a fragment of 300 bases responsible for the cell cycle-specific expression of the TRIDENT gene. (C) 1997 Academic Press.