Effect of praziquantel on the immature stages of Schistosoma haematobium
Effect of praziquantel on the immature stages of Schistosoma haematobium
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DOI：
10.1016/j.ijpara.2005.05.002
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发表时间：
2005-11-01
影响因子：
4
通讯作者：
Cioli, D
中科院分区：
文献类型：
--
作者：
Botros, S;Pica-Mattoccia, L;Cioli, D
已知曼氏血吸虫在感染的开放前期吡喹酮治疗无效。由于埃及血吸虫的潜伏期较长（10-12周，前一种为5-6周），我们提出了一个问题，即尿血吸虫病是否存在相应的较长时间的不敏感期。在感染后不同时间处理的仓鼠中，S。在第5周给予吡喹酮治疗时，嗜血杆菌对吡喹酮部分无效，但在第7-8周及以后的时间表现出几乎完全的敏感性。在感染后不同时间获得的埃及血吸虫蠕虫在体外暴露于吡喹酮，在4至6周之间对低浓度药物难以耐受，但在较高浓度和较晚的时间点明显受到影响。我们得出S.埃及血蜱的吡喹酮不敏感窗口期并不比埃及血蜱长。曼森，尽管它的成熟期要长得多。此外，在较高的药物浓度下可以克服不成熟阶段的难治性。(c)2005年澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
Schistosoma mansoni is known to be refractory to praziquantel treatment in the pre-patent period of infection. Since Schistosoma haematobium has a much longer pre-patent period (10-12 weeks vs. 5-6 for the former species), we asked the question whether a correspondingly longer period of insusceptibility exists in urinary schistosomiasis. In hamsters treated at different times after infection, S. haematobium was partially refractory to praziquantel when treatment was given at week 5, but showed practically full sensitivity at 7-8 weeks and later times. Schistosoma haematobium worms obtained at different times after infection and exposed in vitro to praziquantel were refractory to low drug concentrations between 4 and 6 weeks, but were clearly affected at higher concentrations and at later time points. We conclude that S. haematobium does not have a praziquantel-insensitive window longer than in S. manson, in spite of its much longer maturation period. In addition, refractoriness of immature stages can be overcome at higher drug concentrations. (c) 2005 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.