Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function
Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function
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DOI：
10.1016/j.nbd.2007.11.011
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发表时间：
2008-03-01
影响因子：
6.1
通讯作者：
Cai, Huaibin
中科院分区：
文献类型：
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作者：
Chandran, Jayanth S.;Lin, Xian;Cai, Huaibin
DJ-1基因的功能丧失突变导致了帕金森病（PD）的常染色体隐性遗传形式。为了研究DJ-1在体内的生理功能，我们产生了DJ-1敲除（DJ-1（-/-））小鼠。年轻人（
Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson's disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1(-/-)) mice. Younger (