Nicotine-induced neuroepithelial cell changes in young rabbits: a preliminary communication.
Nicotine-induced neuroepithelial cell changes in young rabbits: a preliminary communication.
复制标题
DOI：
10.1002/ppul.1950010606
复制
发表时间：
1985-11-01
影响因子：
3.1
通讯作者：
Wang, N S
中科院分区：
文献类型：
--
作者：
Chen, M F;Diotallevi, M J;Wang, N S
在妊娠期和哺乳期对3只雌性家兔皮下注射尼古丁（1 mg/kg体重/天），并在产后第5、10和25天通过扫描和透射电子显微镜（SEM和TEM）对后代的肺进行研究。另外三只雌性家兔作为对照。神经上皮小体（NEB）的大小和数量，估计由扫描电镜实验组大于对照组，特别是在第5和25天。此外，尼古丁暴露组的NEB显示正常边界的丧失和细胞和颗粒的紊乱。神经成分也变得突出。这些结果表明，长期母体暴露于尼古丁可能直接或通过神经途径间接诱导兔后代NEB的增生和发育不良。由于NEB被怀疑调节局部支气管和血管平滑肌细胞，这种改变可能类似于吸烟母亲的婴儿呼吸功能障碍。
Nicotine, 1 mg/kg body weight/day, was injected subcutaneously in 3 female rabbits during gestational and lactating periods, and the lungs of the offspring were studied by scanning and transmission electron microscopy (SEM and TEM) on days 5, 10, and 25 postpartum. Three other female rabbits served as controls. The size and number of neuroepithelial bodies (NEB) as estimated by SEM were larger in the experimental group than in the control group, especially on days 5 and 25. Moreover, the NEB in the nicotine-exposed groups showed loss of normal boundaries and derangement of cells and granules by TEM. Neural components also became prominent. These findings suggest that chronic maternal exposure to nicotine may directly, or, through the neural route, indirectly induce hyperplasia and dysplasia of the NEB in the offspring of rabbits. Because NEB are suspected to regulate regional bronchial and vascular smooth muscle cells, such alterations may be similar to respiratory functional impairments found in infants of mothers who smoke.