Obsessive-compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology
Obsessive-compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology
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DOI：
10.1080/01677063.2017.1336236
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发表时间：
2017-01-01
影响因子：
1.9
通讯作者：
Ananloo, Esmaeil Shahsavand
中科院分区：
文献类型：
--
作者：
Bozorgmehr, Ali;Ghadirivasfi, Mohammad;Ananloo, Esmaeil Shahsavand
强迫症（OCD）的特征是经常性的强迫性和重复性行为，通常发生在焦虑之后。在过去的二十年里，对基因序列、大规模和点突变以及基因-基因、基因-环境和基因-药物相互作用的研究已经导致发现了数百个与强迫症相关的基因。虽然每个基因反过来是这种疾病的病因的一部分;然而，强迫症，像其他精神疾病是复杂的，全面和综合的观点是必要的，以了解其遗传基础。本研究通过对现有研究的广泛回顾，找到了所有与强迫症相关的基因，并对这些基因之间的相互作用进行了研究，将其表达为一个相互作用的遗传网络，以整合研究结果。并对重构后的网络进行了分析。研究发现GRIN 2A、GRIN 2B和GRIA 2是网络中最中心的节点。功能和途径富集分析表明，谷氨酸相关途径是强迫症患者的主要缺陷系统。通过研究强迫症和其他疾病之间共享的基因，可以清楚地看到强迫症，癫痫和某些类型的癌症具有最多的共享基因。本研究的结果，除了审查现有的结果作为一个全面和综合的方式，为未来的研究提供了新的假设。
Obsessive-compulsive disorder (OCD) is characterized by recurrent obtrusive and repetitive acts typically occurred following anxiety. In the last two decades, studies done on the gene sequences, large-scale and point mutations and gene-gene, gene-environment and gene-drug interactions have led to the discovery of hundreds of genes associated with OCD. Although each gene in turn is a part of the etiology of this disorder; however, OCD, like other mental disorders is complex and a comprehensive and integrated view is necessary to understand its genetic basis. In this study, through an extensive review of existing published studies, all genes associated with OCD were found. Then, in order to integrate the results, all the interactions between these genes were explored and the achievement was represented as an interactive genetic network. Furthermore, the reconstructed network was analyzed. It was found that GRIN2A, GRIN2B and GRIA2 are the most central nodes in the network. Functional and pathway enrichment analysis showed that glutamate-related pathways are the main deficient systems in patients with OCD. By studying genes shared between OCD and other diseases, it was cleared that OCD, epilepsy and some types of cancer have the most number of shared genes. The results of this study, in addition to reviewing the available results as a comprehensive and integrated manner, provide new hypotheses for future studies.