Primary Glomerulonephritis in Mainland China: An Overview
Primary Glomerulonephritis in Mainland China: An Overview
复制标题
中国大陆原发性肾小球肾炎：概述
DOI：
10.1159/000348642
复制
发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Chen, Nan
中科院分区：
文献类型：
--
作者：
Xie, Jingyuan;Chen, Nan
慢性肾脏疾病（CKD）作为一个全球性的健康问题越来越受到关注，因为它的发病率和患病率不断上升，预后差，相关费用高。原发性肾小球肾炎（GN）是中国CKD和终末期肾脏疾病的主要原因。免疫球蛋白A肾病（IgAN）是最常见的原发性肾小球肾病，占肾活检成年患者的40-50%。有趣的是，中国报道的局灶节段性肾小球硬化（FSGS）的患病率因地理区域而异，膜性肾病的患病率正在上升。家族性FSGS和IgAN在中国很常见，提示其发病机制与遗传因素有关。指导这些肾小球疾病治疗的证据是有限的。大多数中国肾病专家在他们的实践中遵循肾脏疾病：改善全球结果（KDIGO）指南。在此，我们综述了目前中国原发性GN的患病率、病因、临床病理特征和治疗方法。巴塞尔S. Karger股份有限公司版权所有
Chronic kidney disease (CKD) has received increased attention as a global health problem because of its increasing incidence and prevalence, poor outcome and high associated costs. Primary glomerulonephritis (GN) is the leading cause of CKD and end-stage renal disease in China. Immunoglobulin A nephropathy (IgAN) is the most common type of primary GN and accounts for 40-50% of the adult patients undergoing renal biopsy. Interestingly, the reported prevalence of focal segmental glomerulosclerosis (FSGS) in China varies by geographical region, and the prevalence of membranous nephropathy is increasing. Familial FSGS and IgAN are common in China, suggesting that genetic factors are involved in their pathogenesis. The evidence to guide the treatment of these glomerular diseases is limited. Most Chinese nephrologists follow the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines during their practice. Here, we review the current prevalence, etiology, clinicopathological features and treatment of primary GN in China. Copyright (C) 2013 S. Karger AG, Basel