Central catecholamine depletion, vasopressin, and blood pressure in the DOCA/NaCl rat.
Central catecholamine depletion, vasopressin, and blood pressure in the DOCA/NaCl rat.
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DOCA/NaCl 大鼠的中枢儿茶酚胺消耗、加压素和血压。
DOI：
10.1152/ajpheart.1983.244.6.h807
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Oparil,S
中科院分区：
文献类型：
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作者：
Okuno,T;Winternitz,SR;Lindheimer,MD;Oparil,S
为了确定当用6-羟基多巴胺（6-OHDA）进行化学交感神经切除术后防止DOCA-NaCl高血压时是否发生受损的精氨酸加压素（AVP）释放，用脑室内注射6-OHDA（250微克× 2）或Merlis溶液处理的雄性Sprague-Dawley大鼠接受醋酸脱氧皮质酮（DOCA）植入物（100 mg/kg）并饮用0.5%盐水。6-OHDA治疗DOCA/NaCl组的收缩压（139 ± 4 mmHg）低于Merlis-DOCA/NaCl组（183 ± 7 mmHg）（P <0.001）。6-OHDA治疗在整个中枢神经系统中产生广泛的儿茶酚胺耗竭，包括视上核和室旁核，已知其细胞产生AVP，但下丘脑、垂体和血浆AVP水平在两个实验组中相似，后者的平均值为对照组的1.5-2倍。两组大鼠在水负荷时均适当抑制AVP分泌。然而，这样的抑制，对高血压动物的血压没有影响，此外，AVP拮抗剂d（CH 2）5 Tyr（Me）AVP的管理产生的平均血压的两个组，没有显着不同的反应，在控制血压正常大鼠的小的递减。这些数据表明，6-OHDA不能通过降低AVP水平来预防DOCA-NaCl高血压，并表明AVP对于该模型中高血压的维持不是必需的。
To determine whether impaired arginine vasopressin (AVP) release occurs when DOCA-NaCl hypertension is prevented following chemical sympathectomy with 6-hydroxydopamine (6-OHDA), male Sprague-Dawley rats treated with intraventricular injections of 6-OHDA (250 micrograms X 2) or Merlis solution received deoxycorticosterone acetate (DOCA) implants (100 mg/kg) and drank 0.5% saline. Systolic blood pressure in the 6-OHDA-treated DOCA/NaCl group (139 +/- 4 mmHg) was lower (P less than 0.001) than in the Merlis-DOCA/NaCl group (183 +/- 7 mmHg). 6-OHDA treatment produced widespread catecholamine depletion throughout the central nervous system, including the supraoptic and paraventricular nuclei, the cells of which are known to produce AVP, but hypothalamic, pituitary, and plasma AVP levels were similar in both experimental groups, the latter values averaging 1.5–2 times those of controls. Both groups of rats suppressed AVP secretion appropriately when water loaded. Such suppression, however, had no effect on blood pressure in the hypertensive animals and, furthermore, administration of the AVP antagonist d(CH2)5Tyr(Me)AVP produced small decrements in mean blood pressure of both groups that were not significantly different from responses seen in control normotensive rats. These data demonstrate that 6-OHDA does not prevent DOCA-NaCl hypertension by decreasing AVP levels and suggest that AVP is not necessary for the maintenance of hypertension in this model.