Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome
复制标题
肾综合征出血热患者对汉滩病毒感染的细胞因子反应。
DOI：
10.1002/jmv.24752
复制
发表时间：
2017-07-01
影响因子：
12.7
通讯作者：
Zou, Yizhou
中科院分区：
文献类型：
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作者：
Guo, Jing;Guo, Xuli;Zou, Yizhou
汉滩病毒（HTNV）感染人体后会引起一种严重的急性传染病，称为肾综合征出血热（HFRS）。本研究的目的是将患者细胞因子谱与HFRS严重程度相关联。在这项研究中，我们讨论了使用细胞因子信息评估HFRS治疗结果的临床意义。在三组中定量测定18种细胞因子的水平：34例HTNV IgM+病例，63例HTNV IgM阴性病例和78例健康志愿者。患者组血清14种细胞因子水平均高于健康对照组。在34例HTNV IgM+患者血清中，进一步评估了一组27种细胞因子。IgM+组TNF-β、IL-1 ra和IL-6细胞因子水平高于IgM-组。HFRS病情恶化伴随多种细胞因子升高，如IL-1 ra、IL-12 p70、IL-10、IP-10、IL-17、IL-2和IL-6。我们的数据表明，血清细胞因子水平与HFRS的进展。
Hantaan virus (HTNV) infection of the human body causes a severe acute infectious disease known as hemorrhagic fever renal syndrome (HFRS). The aim of this study was to correlate patient cytokine profiles to HFRS severity. In this study, we discuss the clinical significance of evaluating HFRS treatment outcomes using cytokine information. The levels of 18 cytokines were quantitatively determined in three groups: 34 HTNV IgM+ cases, 63 HTNV IgM− negative cases, and 78 healthy volunteers. The level of 14 serum cytokines were higher in the patient group than that in the healthy control group. In the 34 HTNV IgM+ patient sera, a set of 27 cytokines was further assessed. The cytokines of TNF‐β, IL‐1ra, and IL‐6 were detected at higher level in the IgM+ group than that in the IgM− group. The deterioration of HFRS was accompanied with multiple cytokines increased, such as IL‐1ra, IL‐12p70, IL‐10, IP‐10, IL‐17, IL‐2, and IL‐6. Our data indicate that serum cytokine levels are associated with the progression of HFRS.