New furostanol saponins with anti-inflammatory and cytotoxic activities from the rhizomes of Smilax davidiana
New furostanol saponins with anti-inflammatory and cytotoxic activities from the rhizomes of Smilax davidiana
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DOI：
10.1016/j.steroids.2017.08.013
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
黄慧莲
中科院分区：
文献类型：
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作者：
周梦;黄丽萍;李琳玉;韦益飞;舒积成;刘星;黄慧莲
Seven new furostanol saponins have been isolated from the rhizomes of Smilax davidiana. Their structures were.established by 2D NMR spectroscopic techniques (1H,1H-COSY, NOESY, HSQC and HMBC), mass spectrometry.and comparison with the literature. The isolated compounds were subjected to evaluate anti-inflammatory and.cytotoxic activities in vitro. Compounds 3, 5 and 7 were found to have modest anti-inflammatory effects through.suppression of IL-1β production and promote the expression of IL-10 in LPS-stimulated RAW 264.7 cells..Davidianoside F (6) showed activity against MCF-7 and HELA cell lines at the concentration of 10.2 μM and.4.3 μM, respectively.
