Prophylactic acetaminophen does not prevent epidural fever in nulliparous women: a double-blind placebo-controlled trial.
Prophylactic acetaminophen does not prevent epidural fever in nulliparous women: a double-blind placebo-controlled trial.
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DOI：
10.1038/sj.jp.7211128
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发表时间：
2004-08-01
期刊：
影响因子：
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通讯作者：
Suresh, Maya S
中科院分区：
文献类型：
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作者：
Goetzl, Laura;Rivers, Jose;Suresh, Maya S
目的：硬膜外镇痛与未产妇非感染性发热增加4 - 5倍有关。发热预防可以安全地减少不必要的新生儿败血症的评价和潜在的影响，发烧对fetus.Study设计：我们进行了一项随机双盲安慰剂对照研究。在硬膜外放置后，对乙酰氨基酚组和安慰剂组的体温为100.4华氏度的全期无反应率相同（23.8%，p=1.0）。新生儿监测血培养没有发现隐匿性infective.CONCLUSIONS：对乙酰氨基酚预防既不能防止产妇体温过高，也不能防止继发于硬膜外镇痛的发热，这表明发热的机制不包括中枢介导的产妇体温调节紊乱。
OBJECTIVE: Epidural analgesia is associated with a four- to five- fold increase in noninfectious maternal fever in nulliparous women. Fever prophylaxis may safely reduce both unnecessary neonatal sepsis evaluations and the potential effect of fever on the fetus.STUDY DESIGN: We performed a randomized double-blind placebo-controlled study. Immediately after epidural placement, full-term nulliparas with a temperature of 100.4 degrees F was identical in the acetaminophen and placebo groups (23.8%, p=1.0). Neonatal surveillance blood cultures did not reveal occult infection.CONCLUSIONS: Acetaminophen prophylaxis prevented neither maternal hyperthermia nor fever secondary to epidural analgesia, suggesting that the mechanism underlying fever does not include centrally mediated perturbations of maternal thermoregulation.