Axonal swellings in jimpy mice: does lack of myelin cause neuronal abnormalities?
Axonal swellings in jimpy mice: does lack of myelin cause neuronal abnormalities?
复制标题
jimpy 小鼠的轴突肿胀：髓磷脂缺乏是否会导致神经元异常？
DOI：
10.1016/0306-4522(83)90233-6
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发表时间：
1983
期刊：
影响因子：
3.3
通讯作者：
FreidrichJr,VL
中科院分区：
文献类型：
--
作者：
Rosenfeld,J;FreidrichJr,VL
我们在 jimpy（一种髓磷脂缺陷突变小鼠）中观察到局灶性轴突增大。在其他研究中，在另外两只髓磷脂缺陷突变小鼠和一只髓磷脂缺陷突变大鼠中也发现了类似的轴突肿胀。我们认为这种轴突异常代表了髓磷脂缺乏的常见继发反应。这种继发反应也可能发生在包括人类在内的其他物种中，以应对髓磷脂缺乏或疾病导致的髓磷脂损失。
We have observed focal axonal enlargements in jimpy, a myelin deficient mutant mouse. Similar axonal swellings have also been found in other studies, in two other myelin deficient mutant mice and in a myelin deficient mutant rat. We suggest that this axonal abnormality represents a common secondary reaction to lack of myelin. Such a secondary reaction might also occur in other species including human, in response to deficient myelin or to loss of myelin due to disease.