Inhibitory effect of serotonin on feeding behavior in goldfish: Involvement of CRF
Inhibitory effect of serotonin on feeding behavior in goldfish: Involvement of CRF
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DOI：
10.1016/s0196-9781(97)00469-5
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发表时间：
1998-01-01
期刊：
影响因子：
3
通讯作者：
Delgado, MJ
中科院分区：
文献类型：
--
作者：
De Pedro, N;Pinillos, ML;Delgado, MJ
已经研究了 5-HT 对金鱼摄食行为的可能作用。注射后2小时，脑室内（ICV）注射5-羟色胺（5-HT，10μg），食物摄入量显着减少。外周（腹膜内）给予 5-HT（1 和 10 μg/g bw）后，未检测到食物摄入量发生显着变化。因此，可以得出结论，5-HT对硬骨鱼具有中枢厌食作用。考虑到促肾上腺皮质激素释放因子 (CRF) 对硬骨鱼摄食的抑制作用以及哺乳动物中描述的 5-HT 和 CRF 之间的相互作用，我们研究了 CRF 作为金鱼 5-HT 厌食作用介体的可能参与。用α-螺旋CRF[9-41]（20μg）进行ICV预处理部分阻断了5-HT对金鱼摄食的抑制作用。这些结果表明，CRF 至少部分介导金鱼中 5-HT 诱导的摄食抑制。另一方面，ICV处理引起的下丘脑吲哚胺含量的变化表明5-HT激活CRF神经元似乎抑制下丘脑5-羟色胺能传递，支持该神经肽在5-HT对金鱼的中枢厌食作用中的中间作用。 (C) 1998 爱思唯尔科学公司。
The possible action of 5-HT on feeding behavior in goldfish has been studied. Food intake was significantly reduced by intracerebroventricular (ICV) injection of serotonin (5-HT, 10 mu g) at 2 h postinjection. After peripheral (intraperitoneal) administration of 5-HT (1 and 10 mu g/g bw), no significant modifications in food intake were detected. Thus, it can be concluded that there is a central anoretic action of 5-HT in teleost fish. Taking in mind the inhibitory effect of corticotropin releasing factor (CRF) on feeding in teleosts and the interactions between 5-HT and CRF described in mammals, we investigated the possible involvement of CRF as mediator of the 5-HT anoretic action in goldfish. The ICV pretreatment with alpha-Helical CRF[9-41] (20 mu g) partially blocked the inhibitory effect of 5-HT on food consumption in goldfish. These results show that CRF mediates, at least in part, the 5-HT-induced feeding inhibition in goldfish. On the other hand, the alterations in hypothalamic indoleamines content evoked by ICV treatments would suggest that the activation of CRF neurons by 5-HT appears to inhibit hypothalamic serotoninergic transmission, supporting the intermediate role of this neuropeptide in the central anoretic effect of 5-HT in goldfish. (C) 1998 Elsevier Science Inc.