Differences in the Optical Response of MSU and CPP Crystals During Magnetic Orientation: Possibility of Diagnosing Gout and Pseudogout
Differences in the Optical Response of MSU and CPP Crystals During Magnetic Orientation: Possibility of Diagnosing Gout and Pseudogout
复制标题
MSU 和 CPP 晶体在磁取向过程中光学响应的差异：诊断痛风和假性痛风的可能性
DOI：
10.1002/bem.22444
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发表时间：
2023
影响因子：
1.9
通讯作者：
Hamasaki Atom
中科院分区：
文献类型：
--
作者：
Takeuchi Yuka;Yoshikawa Ryotaro;Mitsui Yoshifuru;Iwasaka Masakazu;Matsuda Mizushi;Hamasaki Atom
假性痛风是水晶关节炎。它与痛风的临床表现相似，使用常规分析方法很难区分这两种疾病。然而，重要的是要确定这两种情况下负责不同的晶体，因为治疗策略是不同的。在以前的研究中，我们报告了磁取向的尿酸盐（MSU）晶体，这是痛风的病原体，在永磁体水平。在这项研究中，我们研究了外加磁场对焦磷酸钙（CPP）晶体，这是假性痛风的病因，CPP和MSU晶体的磁响应的差异的影响。我们发现，由于抗磁性磁化率的各向异性，CPP晶体在毫特斯拉量级的磁场中取向。此外，CPP晶体表现出不同的各向异性磁性能从MSU晶体，这导致了两种晶体的取向之间的特征差异。也就是说，我们发现痛风和假性痛风的病原体对磁场的反应不同。本报告表明，通过光学测量区分CPP和MSU是可能的，通过施加适当的磁场。© 2023生物电磁学学会。
Pseudogout is crystalline arthritis. It has a similar clinical picture to that of gout, and it is difficult to distinguish the two diseases using conventional analysis methods. However, it is important to identify the different crystals responsible for these two cases because the treatment strategies are different. In a previous study, we reported magnetic orientation of monosodium urate (MSU) crystals, which are the causative agent of gout, at the permanent magnet level. In this study, we investigated the effect of an applied magnetic field on calcium pyrophosphate (CPP) crystals, which are the causative agent of pseudogout, and the difference in the magnetic responses of CPP and MSU crystals. We found that the CPP crystals were oriented in a magnetic field on milli‐Tesla order because of the anisotropy of the diamagnetic susceptibility. In addition, the CPP crystals exhibited different anisotropic magnetic properties from those of MSU crystals, which led to a characteristic difference between the orientations of the two crystals. That is, we found that the causative agents of gout and pseudogout responded differently to a magnetic field. This report suggests that the discrimination between CPP and MSU by optical measurements is possible by application of magnetic fields appropriately. © 2023 Bioelectromagnetics Society.
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