Diffusion and convection in normal and neoplastic tissues.
Diffusion and convection in normal and neoplastic tissues.
复制标题
DOI：
--
复制
发表时间：
1974-10
期刊：
影响因子：
11.2
通讯作者：
E. Swabb;J. Wei;P. Gullino
中科院分区：
文献类型：
--
作者：
E. Swabb;J. Wei;P. Gullino
摘要通过体内和体外实验测定了肝癌组织和肝癌组织的水导率。建立了一个单一参数来计算溶质在血管外空间的扩散通量与对流通量之比。组织糖胺聚糖含量和溶质分子量是决定溶质血管外运输主要是通过扩散还是通过对流进行的两个最重要的参数。该分析对代谢营养物质和废物、药物、激素、血浆蛋白和病毒在血管外空间的运输具有重要意义。
Summary The hydraulic conductivity of s.c. and hepatocarcinoma tissue was determined by in vivo and in vitro experiments. A single parameter was developed to calculate the ratio of diffusive to convective flux of solutes in the extravascular space. Tissue glycosaminoglycan content and solute molecular weight are the two most important parameters which may determine whether the extravascular transport of solutes occurs predominantly by diffusion or by convection. The analysis has implications for transport of metabolic nutrients and wastes, drugs, hormones, plasma proteins, and viruses in the extravascular space.