IMMUNOHISTOCHEMISTRY OF THE GLIAL FIBRILLARY ACIDIC PROTEIN - BASIC AND APPLIED CONSIDERATIONS
IMMUNOHISTOCHEMISTRY OF THE GLIAL FIBRILLARY ACIDIC PROTEIN - BASIC AND APPLIED CONSIDERATIONS
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DOI：
10.1111/j.1750-3639.1994.tb00837.x
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发表时间：
1994-07-01
期刊：
影响因子：
6.4
通讯作者：
BIGNER, DD
中科院分区：
文献类型：
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作者：
MCLENDON, RE;BIGNER, DD
胶质纤维酸性蛋白的免疫组织化学定位已证明其在中枢神经系统胶质系良性星形胶质细胞和肿瘤细胞的组织学鉴定中的应用。它在神经系统发育中的应用对神经组织的组织发生做出了重要贡献。它在各种形式的损伤和肿瘤中的识别有助于发现星形胶质细胞在这些过程中的功能。在诊断神经病理学方面，它最大的贡献是阐明了以前被认为是谜一样起源的肿瘤的细胞成分。
The immunohistochemical localization of glial fibrillary acidic protein has proven its utility in the histologic identification of benign astrocytes and neoplastic cells of glial lineage in the central nervous system. Its application in the developing nervous system has contributed significantly to following the histogenesis of neural tissue. Its identification in various forms of injury and neoplasia has helped in discovering the function of astrocytes in these processes. In diagnostic neuropathology, its greatest contribution has been in the elucidation of the cellular constituencies of neoplasms previously considered of enigmatic origin.