Endocannabinoid Modulation in the Olfactory Epithelium
Endocannabinoid Modulation in the Olfactory Epithelium
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DOI：
10.1007/978-3-642-14426-4_11
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Schild, Detlev
中科院分区：
文献类型：
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作者：
Breunig, Esther;Czesnik, Dirk;Schild, Detlev
食欲、食物摄入量和能量平衡与中枢神经系统的内源性大麻素系统密切相关。目前，已在非洲爪哇幼虫的外周嗅觉系统中发现了内源性大麻素的调节作用。根据动物的饥饿状态，内源性大麻素2-AG已被证明会影响气味检测阈值。饥饿的动物由于支持细胞中2-AG的合成增强而增加了2-AG的水平。这使得展示CB1受体的嗅觉感受器神经元在检测较低的气味浓度时更敏感，这可能有助于动物定位食物。由于味觉和视觉也受到内源性大麻素的影响，这种调节可能会增加饥饿动物对食物的感觉输入。
Appetite, food intake, and energy balance are closely linked to the endocannabinoid system in the central nervous system. Now, endocannabinoid modulation has been discovered in the peripheral olfactory system of larval Xenopus laevis. The endocannabinoid 2-AG has been shown to influence odorant-detection thresholds according to the hunger state of the animal. Hungry animals have increased 2-AG levels due to enhanced synthesis of 2-AG in sustentacular supporting cells. This renders olfactory receptor neurons, exhibiting CB1 receptors, more sensitive at detecting lower odorant concentrations, which probably helps the animal to locate food. Since taste and vision are also influenced by endocannabinoids, this kind of modulation might boost sensory inputs of food in hungry animals.