Phyllodes Tumor of the Breast Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates
Phyllodes Tumor of the Breast Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates
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DOI：
10.5858/arpa.2016-0042-ra
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发表时间：
2016-07-01
影响因子：
4.6
通讯作者：
Kleer, Celina G.
中科院分区：
文献类型：
--
作者：
Zhang, Yanhong;Kleer, Celina G.
背景：乳腺叶状肿瘤(PT)是一种罕见的纤维上皮性肿瘤，有局部复发和罕见转移的风险。世界卫生组织为PTS提出的良性、交界性和恶性分类是基于几个组织学特征的组合。甲状旁腺瘤和纤维腺瘤的鉴别诊断以及甲状旁腺瘤的组织学分级仍然具有挑战性。此外，甲状旁腺功能亢进的分子发病机制在很大程度上尚不清楚。目的：提供甲状旁腺功能亢进的病理特征、诊断术语和分子改变的最新概述。资料来源。-目前有关乳房甲状旁腺功能亢进的英文文献。结论。-叶状肿瘤表现出广泛的形态。甲状旁腺瘤和纤维腺瘤之间没有明显的界限。严格的组织学评估结合组织学特征和分类可以帮助实现正确的诊断和提供有用的临床信息。从基因组测序中产生的甲状旁腺功能障碍的基因组图谱有助于深入了解甲状旁腺功能亢进的分子发病机制，并有助于提高诊断的准确性和识别恶性甲状旁腺功能障碍的潜在药物靶点。
Context.-Phyllodes tumor (PT) of the breast is a rare fibroepithelial neoplasm with risks of local recurrence and uncommon metastases. The classification proposed by the World Health Organization for PTs into benign, borderline, and malignant is based on a combination of several histologic features. The differential diagnosis between PT and fibroadenoma and the histologic grading of PT remain challenging. In addition, the molecular pathogenesis of PT is largely unknown.Objective.-To provide an updated overview of pathologic features, diagnostic terminology, and molecular alterations of PT.Data Sources.-Current English literature related to PT of the breast.Conclusions.-Phyllodes tumor shows a wide spectrum of morphology. There are no clearly distinct boundaries between PT and fibroadenoma. Strict histologic assessment of a combination of histologic features with classification can help to achieve the correct diagnosis and provide useful clinical information. The genomic landscapes of PT generated from genomic sequencing provide insights into the molecular pathogenesis of PT and help to improve diagnostic accuracy and identify potential drug targets in malignant PT.