Development of a tissue engineering scaffold structure library for rapid prototyping. Part 2: Parametric library and assembly program
Development of a tissue engineering scaffold structure library for rapid prototyping. Part 2: Parametric library and assembly program
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DOI：
10.1007/s001700300035
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发表时间：
2003-01-01
影响因子：
3.4
通讯作者：
Chua, SW
中科院分区：
文献类型：
--
作者：
Chua, CK;Leong, KF;Chua, SW
已经发现快速成型（RP）技术对于组织工程（TE）支架制造是有利的，这是由于它们能够解决和克服在常规处理技术中发现的复杂三维结构的不可控制的微观结构和可行性问题的问题。本研究提出了一种新的方法，TE支架制造使用RP技术。该方法包括整合医学成像设备（CT/MRI）用于采集解剖结构数据，三维CAD建模用于设计和创建数字支架模型和RP用于制造物理支架。为辅助用户进行CAD建模，设计并开发了脚手架结构标准参数库。使用该库，用户可以选择支架单元的几何形状并调整其大小以适合TE支架的最终应用。然后，开发的应用程序将根据待复制的解剖结构的表面轮廓，从所选择的单位单元组装支架结构。然后将使用RP系统建造物理脚手架。
Rapid prototyping (RP) techniques have been found to be advantageous for tissue engineering (TE) scaffold fabrication due to their ability to address and overcome the problems of uncontrollable microstructure and the feasibility issues of complex three-dimensional structures found in conventional processing techniques. This research proposes a novel approach for TE scaffold manufacture using RP techniques. The approach involves the integration of medical imaging devices (CT/MRI) for the acquisition of anatomic structural data, three-dimensional CAD modelling for designing and creating the digital scaffold models and RP for fabricating the physical scaffolds. To aid the user in CAD modelling, a standard parametric library of scaffold structures is designed and developed. With the library, a user can select the geometry of the scaffold unit cell and size it to suit the end application of the TE scaffold. A developed application program will then assemble the scaffold structure from the selected unit cell, following the surface profile of the anatomic structure to be replicated. A physical scaffold will then be built using an RP system.