Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain α-synuclein immunoreactivity
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DOI：
10.1097/00005072-199804000-00005
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发表时间：
1998-04-01
影响因子：
3.2
通讯作者：
Hyman, BT
中科院分区：
文献类型：
--
作者：
Irizarry, MC;Growdon, W;Hyman, BT
α-突触核蛋白基因的突变最近与一些家族性帕金森病（PD）病例有关。我们的特点是这种突触前蛋白的表达在中脑，纹状体，颞叶皮质的控制，PD和路易体痴呆（DLB）的大脑。对照组脑细胞周免疫染色呈点状。PD脑表现出α-突触核蛋白免疫反应性黑质路易体，苍白体和异常的神经突起。PD脑中罕见的神经元索马胞体对α-突触核蛋白呈免疫反应性。DLB病例证明了这些发现以及皮质路易体和CA 2 -3神经突中的α-突触核蛋白免疫反应性。这些结果表明，即使在散发病例中，α-突触核蛋白在PD和神经病理相关疾病DLB的发病机制中也具有早期和直接的作用。
A mutation in the alpha-synuclein gene has recently been linked to some cases of familial Parkinson's disease (PD). We characterized the expression of this presynaptic protein in the midbrain, striatum, and temporal cortex of control, PD, and dementia with Lewy bodies (DLB) brain. Control brain showed punctate pericellular immunostaining. PD brain demonstrated alpha-synuclein immunoreactivity in nigral Lewy bodies, pale bodies and abnormal neurites. Rare neuronal soma in PD brain were immunoreactive for alpha-synuclein. DLB cases demonstrated these findings as well as alpha-synuclein immunoreactivity in cortical Lewy bodies and CA2-3 neurites. These results suggest that, even in sporadic cases, there is an early and direct role for alpha-synuclein in the pathogenesis of PD and the neuropathologically related disorder DLB.