Cell culture - Progenitor cells from human brain after death
Cell culture - Progenitor cells from human brain after death
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DOI：
10.1038/35075141
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发表时间：
2001-05-03
期刊：
影响因子：
64.8
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
Palmer, TD;Schwartz, PH;Gage, FH
从成年啮齿动物脑中培养神经祖细胞已成为常规，也可以从人胎儿组织中培养，但从出生后和成年人组织中扩增这些细胞，尽管出于伦理原因是优选的，但遇到了问题。在这里，我们描述了从人类死后组织和手术标本中分离和成功增殖神经前体细胞。虽然成人和胎儿祖细胞的相对治疗优点仍然需要评估，我们的研究结果可能会扩大这些祖细胞在神经退行性疾病的治疗中的应用。
Culturing neural progenitor cells from the adult rodent brain has become routine,and is also possible from human fetal tissue,, but expansion of these cells from postnatal and adult human tissue, although preferred for ethical reasons, has encountered problems,,,. Here we describe the isolation and successful propagation of neural progenitor cells from human postmortem tissues and surgical specimens. Although the relative therapeutic merits of adult and fetal progenitor cells still need to be assessed, our results may extend the application of these progenitor cells in the treatment of neurodegenerative diseases.