Associations of chemical composition and sources of PM2.5 with lung function of severe asthmatic adults in a low air pollution environment of urban Nagasaki, Japan
Associations of chemical composition and sources of PM2.5 with lung function of severe asthmatic adults in a low air pollution environment of urban Nagasaki, Japan
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DOI：
10.1016/j.envpol.2019.05.117
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发表时间：
2019-09-01
影响因子：
8.9
通讯作者：
Mukae, Hiroshi
中科院分区：
文献类型：
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作者：
Ng, Chris Fook Sheng;Hashizume, Masahiro;Mukae, Hiroshi
以往的研究已将环境PM2.5与肺功能下降联系起来，但具体化学元素和排放源对重度哮喘的影响尚不清楚。我们研究了日本长崎市低空气污染环境中PM2.5的质量、化学成分和来源与严重哮喘成人肺功能的短期关系。我们招募了35名哮喘成年人，并获得了2014-2016年春季的每日晨峰呼气流量（PEF）记录。从空气质量监测站（178天）提取PM2.5过滤器，并测量27种化学元素。使用正矩阵分解（PMF）进行源解析。我们用广义估计方程（GEE）方法拟合广义线性模型，以估计与PM2.5的质量、成分和来源相关的PEF（从个人每月最大值）变化和严重呼吸恶化的几率（1周间隔内首次>= 15%PEF降低），并对温度和相对湿度进行调整。SO 42-和PM2.5与PEF降低有关。SO 42-的四分位距（IQR）增加（3.7 μ g/m3，平均滞后0-1）与0.38%的下降相关（95%置信区间= -0.75%至-0.001%）。石油燃烧和交通来源的PM2.5的IQR增加（2.64 μ g/m（3），滞后1）与033%的下降（-0.62%至-0.002%）相关。我们发现一个更大的PEF下降与PM2.5从灰尘/土壤在亚洲沙尘天。没有证据表明总质量和金属与肺功能降低有关。重度哮喘成人的呼吸能力易受PM2.5的特定成分/来源（如硫酸盐和石油燃烧和交通）的影响，尽管研究地点的哮喘和空气污染水平较低。(C)2019爱思唯尔有限公司版权所有。
Previous studies have linked ambient PM2.5 to decreased pulmonary function, but the influence of specific chemical elements and emission sources on the severe asthmatic is not well understood. We examined the mass, chemical constituents, and sources of PM2.5 for short-term associations with the pulmonary function of adults with severe asthma in a low air pollution environment in urban Nagasaki, Japan. We recruited 35 asthmatic adults and obtained the daily record of morning peak expiratory flow (PEF) in spring 2014-2016. PM2.5 filters were extracted from an air quality monitoring station (178 days) and measured for 27 chemical elements. Source apportionment was performed using Positive Matrix Factorization (PMF). We fitted generalized linear model with generalized estimating equation (GEE) method to estimate changes in PEF (from personal monthly maximum) and odds of severe respiratory deterioration (first >= 15% PEF reduction within a 1-week interval) associated with mass, constituents, and sources of PM2.5, with adjustment for temperature and relative humidity. Constituent sulfate (SO42-) and PM2.5 from oil combustion and traffic were associated with reduced PEF. An interquartile range (IQR) increase in SO42- (3.7 mu g/m(3), average lags 0-1) was associated with a decrease of 0.38% (95% confidence interval = -0.75% to -0.001%). An IQR increase in oil combustion and traffic-sourced PM2.5 (2.64 mu g/m(3), lag 1) was associated with a decrease of 033% (-0.62% to -0.002%). We found a larger PEF decrease associated with PM2.5 from dust/soil on Asian Dust days. There was no evidence linking total mass and metals to reduced pulmonary function. The ventilatory capacity of adults with severe asthma is susceptible to specific constituents/sources of PM2.5 such as sulfate and oil combustion and traffic despite active self-management of asthma and low air pollution levels in the study location. (C) 2019 Elsevier Ltd. All rights reserved.