RELATION BETWEEN EXTENT OF CORONARY-ARTERY DISEASE AND BLOOD-VISCOSITY
RELATION BETWEEN EXTENT OF CORONARY-ARTERY DISEASE AND BLOOD-VISCOSITY
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DOI：
10.1136/bmj.280.6215.673
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
BARBENEL, JC
中科院分区：
文献类型：
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作者：
LOWE, GDO;DRUMMOND, MM;BARBENEL, JC
本文测定了50例30~55岁男性冠状动脉造影术前的全血粘度(切变率100/S)及其主要决定因素(红细胞压积、血浆纤维蛋白原浓度和血浆粘度)，并与冠状动脉病变程度相关。26名男性有广泛的疾病(两条或三条主要冠状动脉狭窄)，24名男性只有一条血管狭窄或没有狭窄。26例广泛性疾病患者的平均全血粘度显著高于轻度或无疾病患者和25例健康对照组(P<0.001)。粘度的增加部分是由于较高的填充细胞体积，部分是由于较高的纤维蛋白原浓度；血浆粘度没有明显增加。这些差异不能用吸烟史来解释。这些结果表明，男性血液粘度升高与广泛的冠状动脉疾病之间存在关联，值得进一步研究。
Blood viscosity (shear rate 100/s) and its major determinants (packed cell volume, plasma fibrinogen concentration, and plasma viscosity) were measured before coronary angiography in 50 men aged 30-55 and related to the extent of coronary artery disease. Twenty-six men had extensive disease (stenosis of two or three major coronary vessels), and 24 had either stenosis of one vessel or no stenosis. The 26 men with extensive disease had significantly higher mean blood viscosity than those with mild or no disease and 25 healthy controls (p less than 0.001). The increased viscosity was due partly to a higher packed cell volume and partly to a higher fibrinogen concentration; plasma viscosity was not significantly increased. These differences could not be explained by smoking history. These results suggest an association between increased blood viscosity and extensive coronary artery disease in men, which merits further investigation.