Long-term effects of recombinant human insulin-like growth factor I treatment on glucose and lipid metabolism and the growth of a patient with congenital generalized lipodystrophy.
Long-term effects of recombinant human insulin-like growth factor I treatment on glucose and lipid metabolism and the growth of a patient with congenital generalized lipodystrophy.
复制标题
重组人胰岛素样生长因子 I 治疗对先天性全身性脂肪营养不良患者的葡萄糖和脂质代谢以及生长的长期影响。
作者：
M. Satoh;A. Yoshizawa;M. Takesue;T. Saji;S. Yokoya
先天性全身性脂肪营养不良（CGL）是一种以全身性脂肪缺乏、胰岛素抵抗、高脂血症和脂肪肝为特征的疾病。我们研究了重组人胰岛素样生长因子I（rhIGF-I）治疗对CGL患者糖脂代谢和生长的长期影响。在rhIGF-I治疗期间，血清甘油三酯水平几乎维持在正常范围内，血浆糖化血红蛋白A1 c（HbA 1c）水平维持在8.0%以下（5.8%-7.9%）。因此，rhIGF-I治疗在CGL患者中长期降低葡萄糖和甘油三酯水平是有效的。但是，却很难抑制住病人的食欲。尽管血清总IGF-I水平极高（1000-1700 ng/ml），但在rhIGF-I处理开始后生长未加速，可能是因为正常的IGF结合蛋白3（IGFBP-3）水平。在rhIGF-I治疗期间，患者出现轻度肥厚性心肌病复发和轻度眼内压升高。
Congenital generalized lipodystrophy (CGL) is a disease characterized by generalized lack of body fat, insulin resistance, hypertriglyceridemia, and fatty liver. We studied the long-term effects of recombinant human insulin-like growth factor I (rhIGF-I) treatment on glucose and lipid metabolism and the growth in a patient with CGL. During rhIGF-I treatment, the serum triglyceride level was maintained almost within the normal range, and the plasma glycosylated hemoglobin A1c (HbA1c) levels were maintained under 8.0% (5.8%-7.9%). Thus, rhIGF-I treatment was effective in lowering glucose and triglyceride levels over the long-term in a CGL patient. However, it was difficult to suppress the patient's voracious appetite. Although serum total IGF-I levels were extremely high (1000-1700 ng/ml), growth was not accelerated after the start of rhIGF-I treatment, likely because of normal IGF binding protein 3 (IGFBP-3) levels. During rhIGF-I treatment, the patient developed a recurrence of mild hypertrophic cardiomyopathy and a mild elevation of intraocular pressure.
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DOI：
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