Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis.
Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis.
复制标题
硫酸软骨素6抑制小鼠皮肤角质细胞增殖，这与牛皮癣有关。
DOI：
10.1038/s42003-020-01618-5
复制
发表时间：
2021-01-25
影响因子：
5.9
通讯作者：
Kitagawa H
中科院分区：
文献类型：
--
作者：
Kitazawa K;Nadanaka S;Kadomatsu K;Kitagawa H
硫酸软骨素与表皮生物学有关，但硫酸软骨素的功能意义尚不清楚。在这里，我们报告说，软骨素6-硫酸是重要的维持表皮稳态。软骨素6-O-磺基转移酶-1（C6 st-1）参与软骨素6-硫酸盐的生物合成，缺乏C6 st-1的小鼠表现出角质形成细胞过度增殖和皮肤通透性屏障功能受损。软骨素6-硫酸盐直接与EGF受体相互作用，并负性控制配体诱导的EGF受体信号传导。过度增殖的C6 st-1基因敲除小鼠来源的角质形成细胞的正常功能通过用外源性6-硫酸软骨素治疗而被拯救。使用咪喹莫特诱导的表皮增生在C6 st-1敲除小鼠中比在C6 st-1野生型小鼠中更严重。总之，这些发现表明，软骨素6-硫酸抑制角质形成细胞在正常皮肤的增殖，C6 st-1的表达水平可能与银屑病的易感性。Kitazawa等人表明6-硫酸软骨素抑制皮肤中的角质形成细胞增殖。他们发现，缺乏软骨素-6-O-磺基转移酶-1（C6 st-1）的小鼠表现出角质形成细胞过度增殖和皮肤渗透屏障受损。提示C6 st-1表达水平可作为银屑病易感性的生物标志物。
Chondroitin sulfates are implicated in epidermal biology, but functional significance of chondroitin sulfates remains unclear. Here, we report that chondroitin 6-sulfate is important for the maintenance of epidermal homeostasis. Mice deficient in chondroitin 6-O-sulfotransferase-1 (C6st-1), which is involved in biosynthesis of chondroitin 6-sulfate, exhibited keratinocyte hyperproliferation and impaired skin permeability barrier function. Chondroitin 6-sulfate directly interacted with the EGF receptor and negatively controlled ligand-induced EGF receptor signaling. Normal function of hyperproliferative C6st-1-knockout mouse-derived keratinocytes was rescued by treatment with exogenous chondroitin 6-sulfate. Epidermal hyperplasia, induced using imiquimod, was more severe in C6st-1-knockout mice than in C6st-1 wild-type mice. Taken together, these findings indicate that chondroitin 6-sulfate represses keratinocyte proliferation in normal skin, and that the expression level of C6st-1 may be associated with susceptibility to psoriasis. Kitazawa et al. show that chondroitin 6-sulfate represses keratinocyte proliferation in skin. They find that mice deficient in chondroitin-6-O-sulfotransferase-1 (C6st-1), which synthesizes chondroitin 6-sulfate, exhibit keratinocyte hyperproliferation and impaired skin permeability barrier. This study suggests that the expression level of C6st-1 may serve as a biomarker for the susceptibility to psoriasis.
登录
查看更多内容
影响因子：
4.8
作者：
Nadanaka, Satomi;Ishida, Miho;Kitagawa, Hiroshi
通讯作者：
Kitagawa, Hiroshi
影响因子：
5.6
作者：
Bocheńska K;Smolińska E;Moskot M;Jakóbkiewicz-Banecka J;Gabig-Cimińska M
通讯作者：
Gabig-Cimińska M
影响因子：
6.8
作者：
Pantazopoulos H;Markota M;Jaquet F;Ghosh D;Wallin A;Santos A;Caterson B;Berretta S
通讯作者：
Berretta S
影响因子：
4.5
作者：
Eames BF;Yan YL;Swartz ME;Levic DS;Knapik EW;Postlethwait JH;Kimmel CB
通讯作者：
Kimmel CB
影响因子：
14
作者：
Hanthamrongwit, M;Reid, WH;Grant, MH
通讯作者：
Grant, MH